Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance (Q35467835)

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English	Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance	scientific article

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scholarly article

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Europe PubMed Central

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16 June 2018

http://europepmc.org/abstract/PMC/5894481

Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance (English)

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Europe PubMed Central

PMC publication ID

16 June 2018

http://europepmc.org/abstract/PMC/5894481

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lymphoblastic leukemia

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Maximilian Mossner

3

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10 June 2020

12

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10 June 2020

17

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10 June 2020

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Daniel Nowak

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10 June 2020

Natalia L M Liem

2

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10 June 2020

Marion Klaumünzer

4

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10 June 2020

Rachael A Papa

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10 June 2020

Verena Nowak

6

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10 June 2020

Johann C Jann

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10 June 2020

Tadayuki Akagi

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10 June 2020

Norihiko Kawamata

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10 June 2020

Ryoko Okamoto

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10 June 2020

Nils H Thoennissen

11

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10 June 2020

Masashi Sanada

13

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10 June 2020

Wolf-Karsten Hofmann

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10 June 2020

Seishi Ogawa

15

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10 June 2020

Glenn M Marshall

16

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10 June 2020

H Phillip Koeffler

18

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10 June 2020

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publication date

29 October 2014

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16 June 2018

http://europepmc.org/abstract/PMC/5894481

Experimental Hematology

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10 June 2020

43

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10 June 2020

1

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10 June 2020

32-43.e1-35

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10 June 2020

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Acute lymphoblastic leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

1 reference

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27 July 2018

Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Glucocorticoid receptor-mediated apoptosis: mechanisms of resistance in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Novel in vivo model of inducible multi-drug resistance in acute lymphoblastic leukemia with chromosomal translocation t(4;11)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Defective expression of deoxycytidine kinase in cytarabine-resistant acute myeloid leukemia cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

In vivo models of childhood leukemia for preclinical drug testing

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27 July 2018

Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays

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27 July 2018

Xenograft models for the preclinical evaluation of new therapies in acute leukemia

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27 July 2018

Characterization of resistance to cytosine arabinoside (Ara-C) in NALM-6 human B leukemia cells

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27 July 2018

A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays

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27 July 2018

Substrate cycles and drug resistance to 1-beta-D-arabinofuranosylcytosine (araC).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Vincristine revisited

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27 July 2018

Ara-C: cellular and molecular pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

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27 July 2018

Role of folylpolygutamate synthetase (FPGS) in antifolate chemotherapy; a biochemical and clinical update

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27 July 2018

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

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27 July 2018

Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

27 July 2018

Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo

1 reference

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27 July 2018

Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.

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26 September 2018

Genetic variegation of clonal architecture and propagating cells in leukaemia

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26 September 2018

Acute lymphoblastic leukemia cells that survive combination chemotherapy in vivo remain sensitive to allogeneic immune effects

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26 September 2018

Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.

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26 September 2018

Studying the genotoxicity of vincristine on human lymphocytes using comet assay, micronucleus assay and TCR gene mutation test in vitro.

1 reference

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26 September 2018

Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia.

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26 September 2018

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

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26 September 2018

Molecular basis for decreased folylpoly-gamma-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell line

1 reference

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26 September 2018

Cytosine arabinoside affects multiple cellular factors and induces drug resistance in human lymphoid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

26 September 2018

Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894481

26 September 2018

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

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15 November 2018

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/25450514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of genetic variation in the folylpolyglutamate synthase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/25450514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic studies on 2',2'-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25450514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.EXPHEM.2014.09.007

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25450514%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PMC publication ID

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Europe PubMed Central

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10 June 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25450514%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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