Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery (Q35389422)

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English	Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery	scientific article

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scholarly article

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Europe PubMed Central

8 August 2017

Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery (English)

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Europe PubMed Central

8 August 2017

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Munir Pirmohamed

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Munir Pirmohamed

4

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author name string

Nasir Mirza

1

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Europe PubMed Central

8 August 2017

Olga Vasieva

2

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Europe PubMed Central

8 August 2017

Anthony Guy Marson

3

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Europe PubMed Central

8 August 2017

publication date

18 August 2011

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Europe PubMed Central

8 August 2017

Human Molecular Genetics

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Europe PubMed Central

8 August 2017

20

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Europe PubMed Central

8 August 2017

4381-4394

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Europe PubMed Central

8 August 2017

22

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Europe PubMed Central

8 August 2017

SLC22 transporter family proteins as targets for cytostatic uptake into tumor cells

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Cholecystokinin: a multi-functional molecular switch of neuronal circuits

1 reference

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12 July 2018

The emerging role for chemokines in epilepsy

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12 July 2018

Characterization, using comparative proteomics, of differentially expressed proteins in the hippocampus of the mesial temporal lobe of epileptic rats following treatment with valproate

1 reference

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12 July 2018

Endogenous SNAP-25 regulates native voltage-gated calcium channels in glutamatergic neurons

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12 July 2018

Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays.

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12 July 2018

The mechanisms of medically refractory temporal lobe epilepsy

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12 July 2018

Pharmacogenetic association study of 30 genes with phenobarbital drug response in epileptic dogs

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12 July 2018

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population

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12 July 2018

Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity

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12 July 2018

Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.

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12 July 2018

New developments in antiepileptic drug resistance: an integrative view

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12 July 2018

Global expression profiling in epileptogenesis: does it add to the confusion?

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Membrane fusion: grappling with SNARE and SM proteins

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12 July 2018

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

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12 July 2018

Intrinsic severity as a determinant of antiepileptic drug refractoriness

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12 July 2018

Overexpression of N-WASP in the brain of human epilepsy

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12 July 2018

The clinical impact of pharmacogenetics on the treatment of epilepsy

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12 July 2018

One of the hottest topics in epileptology: ABC proteins. Their inhibition may be the future for patients with intractable seizures

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12 July 2018

Neurogenesis in the human hippocampus and its relevance to temporal lobe epilepsies.

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12 July 2018

Stabilizing dendritic structure as a novel therapeutic approach for epilepsy

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12 July 2018

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

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12 July 2018

Possible role of the innate immunity in temporal lobe epilepsy.

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12 July 2018

IQ-motif proteins influence intracellular free Ca2+ in hippocampal neurons through their interactions with calmodulin

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12 July 2018

Elevated p53 and lower MDM2 expression in hippocampus from patients with intractable temporal lobe epilepsy

1 reference

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12 July 2018

ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy

1 reference

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12 July 2018

Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes

1 reference

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12 July 2018

Seizure-promoting effect of blood-brain barrier disruption

1 reference

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12 July 2018

TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196887

12 July 2018

Serial analysis of gene expression in the hippocampus of patients with mesial temporal lobe epilepsy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196887

12 July 2018

Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis

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12 July 2018

Brain inflammation in epilepsy: experimental and clinical evidence

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12 July 2018

Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy

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12 July 2018

Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.

1 reference

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12 July 2018

A Greater Role for Surgical Treatment of Epilepsy: Why and When?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196887

12 July 2018

Integrins, synaptic plasticity and epileptogenesis.

1 reference

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12 July 2018

The neurobiology of antiepileptic drugs

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12 July 2018

Large-scale analysis of gene expression in epilepsy research: is synthesis already possible?

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12 July 2018

Identifying biological themes within lists of genes with EASE

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12 July 2018

TGF-betas and their roles in the regulation of neuron survival

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12 July 2018

Fibroblast growth factors and neuroprotection

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12 July 2018

The natural history of epilepsy in the era of new antiepileptic drugs and surgical treatment

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12 July 2018

Transcriptional profiling in human epilepsy: expression array and single cell real-time qRT-PCR analysis reveal distinct cellular gene regulation

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12 July 2018

Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?

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12 July 2018

Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis

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12 July 2018

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12 July 2018

Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus.

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12 July 2018

How does calcium trigger neurotransmitter release?

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12 July 2018

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

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The epidemiology and treatment of chronic and refractory epilepsy

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The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules

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Alterations in cholecystokinin peptide and mRNA in actively epileptic human temporal cortical foci

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12 July 2018

Gene expression analysis on anterior temporal neocortex of patients with intractable epilepsy.

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26 September 2018

Cholecystokinin-8 sulfate modulates the anticonvulsant efficacy of vigabatrin in an experimental model of partial complex epilepsy in the rat.

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26 September 2018

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

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26 September 2018

Carbamazepine protects against neuronal hyperplasia and abnormal gene expression in the megencephaly mouse

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26 September 2018

Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy.

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26 September 2018

Upregulated expression of postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA in temporal lobe tissue of epilepsy.

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26 September 2018

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26 September 2018

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26 September 2018

Decreased expression of thyroid receptor-associated protein 220 in temporal lobe tissue of patients with refractory epilepsy.

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26 September 2018

Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy

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26 September 2018

Large-scale expression study of human mesial temporal lobe epilepsy: evidence for dysregulation of the neurotransmission and complement systems in the entorhinal cortex.

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26 September 2018

Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling.

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26 September 2018

Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy

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26 September 2018

Combining multiple microarray studies and modeling interstudy variation.

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26 September 2018

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26 September 2018

Differential phosphorylation of syntaxin and synaptosome-associated protein of 25 kDa (SNAP-25) isoforms

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26 September 2018

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26 September 2018

Effect of CCK-8 on audiogenic epileptic seizure in P77PMC rats.

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26 September 2018

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26 September 2018

Suppression of audiogenic epileptic seizures by intracerebral injection of a CCK gene vector.

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Cholecystokinin blocks some effects of kainic acid in CA3 region of hippocampal slices

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Gene expression profile analysis by DNA microarrays: promise and pitfalls

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Complexin: does it deserve its name?

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10.1093/HMG/DDR365

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Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

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