The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation (Q35371834)

8 August 2017

The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation (English)

1 reference

ubiquitin-proteasome system

8 August 2017

0 references

author name string

Yong-Sam Jung

series ordinal

1

1 reference

8 August 2017

Yingjuan Qian

series ordinal

2

1 reference

8 August 2017

Xinbin Chen

series ordinal

3

1 reference

8 August 2017

language of work or name

English

0 references

publication date

18 August 2011

1 reference

Journal of Biological Chemistry

8 August 2017

1 reference

8 August 2017

286

1 reference

8 August 2017

41

1 reference

8 August 2017

35388-35395

1 reference

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

8 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Therapeutic prospects for p73 and p63: rising from the shadow of p53.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

p63 and p73 in human cancer: defining the network

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

p53 ubiquitination: Mdm2 and beyond

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

The ubiquitin-protein ligase Itch regulates p73 stability

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

The common and distinct target genes of the p53 family transcription factors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

p21Waf1/Cip1 as a therapeutic target in breast and other cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Transactivation-deficient DeltaTA-p73 acts as an oncogene.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Role of the p53-homologue p73 in E2F1-induced apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Role for the p53 homologue p73 in E2F-1-induced apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Mdm2 binds p73 alpha without targeting degradation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

The expression of p73 is increased in lung cancer, independent of p53 gene alteration

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

MDM2 suppresses p73 function without promoting p73 degradation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Definition of a consensus binding site for p53

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

T antigen is bound to a host protein in SY40-transformed cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195599

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

27 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.261537

p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.261537

Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.261537

Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.261537

Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.261537

Expression of Pirh2, a p27(Kip1) ubiquitin ligase, in hepatocellular carcinoma: correlation with p27(Kip1) and cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.261537

The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.261537

A novel oncoprotein Pirh2: rising from the shadow of MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.261537

UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.261537

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

21 January 2018

1 reference

12 December 2020

The continuing saga of p53--more sleepless nights ahead

1 reference

12 December 2020

Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA

1 reference

12 December 2020

p53 ancestry: gazing through an evolutionary lens

1 reference

12 December 2020

p73 is transcriptionally regulated by DNA damage, p53, and p73

1 reference

12 December 2020

Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation

1 reference

12 December 2020

p73 overexpression is a prognostic factor in patients with colorectal adenocarcinoma

1 reference

12 December 2020

Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation

1 reference

12 December 2020

Chemosensitivity linked to p73 function

1 reference

12 December 2020

Overexpression of the wild type p73 gene in breast cancer tissues and cell lines

1 reference

12 December 2020

Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.261537

1 reference

release_qhqeeq2thzcr3l66y2kmbugnxe

8 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qhqeeq2thzcr3l66y2kmbugnxe

24 November 2022

mapped directly with Wikidata item

PMCID

3195599

1 reference

8 August 2017

1 reference