Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy (Q35368220)

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21 February 2020

title

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy (English)

1 reference

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21 February 2020

1 reference

1

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21 February 2020

Lucas B Sullivan

series ordinal

2

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21 February 2020

author name string

Matthew G Vander Heiden

series ordinal

3

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21 February 2020

publication date

24 October 2014

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21 February 2020

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21 February 2020

volume

12

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21 February 2020

page(s)

82

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Creative Commons Attribution 4.0 International

21 February 2020

copyright license

start time

24 October 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1186/s12915-014-0082-4

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cites work

Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

LKB1 and AMPK and the cancer-metabolism link - ten years after

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

Investigating metformin for cancer prevention and treatment: the end of the beginning

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

Metformin directly acts on mitochondria to alter cellular bioenergetics.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

Metformin suppresses intestinal polyp growth in ApcMin/+ mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207883

10.1186/S12915-014-0082-4

26 September 2018

Identifiers

DOI

1 reference

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Dimensions Publication ID

21 February 2020

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21 February 2020

1 reference

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