Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft. (Q35329755)

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9 February 2020

title

Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft (English)

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9 February 2020

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1 reference

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2

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9 February 2020

Ian J Stratford

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Stephen R Wedge

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9 February 2020

4

Cian M McCrudden

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9 February 2020

5

David G Hirst

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9 February 2020

author name string

Joana M Senra

1

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9 February 2020

Kim E Cherry

3

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9 February 2020

Mark J O'Connor

6

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9 February 2020

publication date

8 August 2011

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Molecular Cancer Therapeutics

9 February 2020

published in

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9 February 2020

volume

10

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9 February 2020

page(s)

1949-1958

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9 February 2020

issue

10

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Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer

9 February 2020

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

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Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair

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Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: a contributory factor to chemopotentiation in vivo?

12 July 2018

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Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427.

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

12 July 2018

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In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016.

12 July 2018

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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

12 July 2018

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Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential

12 July 2018

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4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

12 July 2018

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Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

12 July 2018

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A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia

12 July 2018

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Targeted cancer therapies based on the inhibition of DNA strand break repair

12 July 2018

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Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models

12 July 2018

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ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

12 July 2018

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The concept of synthetic lethality in the context of anticancer therapy

12 July 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

12 July 2018

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

12 July 2018

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12 July 2018

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ARCON: a novel biology-based approach in radiotherapy

12 July 2018

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Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited

12 July 2018

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The response of Parp knockout mice against DNA damaging agents.

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Nicotinamide exerts different acute effects on microcirculatory function and tissue oxygenation in rat tumors

12 July 2018

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12 July 2018

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The influence of inhibitors of poly (ADP-ribose) polymerase on X-ray-induced potentially lethal damage repair

12 July 2018

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Inhibitors of poly (ADP-ribose) synthesis enhance radiation response by differentially affecting repair of potentially lethal versus sublethal damage

12 July 2018

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12 July 2018

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Mechanism of action of the selective tumor radiosensitizer nicotinamide

12 July 2018

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Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation.

12 July 2018

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Effect of nicotinamide on the microregional heterogeneity of oxygen delivery within a murine tumor

12 July 2018

1 reference

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Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

12 July 2018

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Nicotinamide relaxes vascular smooth muscle by inhibiting myosin light chain kinase-dependent signaling pathways: implications for anticancer efficacy.

26 September 2018

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Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

26 September 2018

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The modification of blood flow in tumours and their supplying arteries by nicotinamide.

26 September 2018

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Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit

26 September 2018

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12 December 2020

(ADP-ribose)n participates in DNA excision repair

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12 December 2020

Inhibitors of Poly(ADP-Ribose) Synthesis Enhance X-Ray Killing of Log-Phase Chinese Hamster Cells

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12 December 2020

The radiosensitizer nicotinamide inhibits arterial vasoconstriction

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12 December 2020

10.1158/1535-7163.MCT-11-0278

Identifiers

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