Secretases as targets for the treatment of Alzheimer's disease: the prospects (Q35172392)

6 August 2017

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title

Secretases as targets for the treatment of Alzheimer's disease: the prospects (English)

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6 August 2017

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1

Ilse Dewachter

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6 August 2017

2

Fred Van Leuven

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6 August 2017

1 November 2002

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6 August 2017

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6 August 2017

1

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6 August 2017

7

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6 August 2017

409-416

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity

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https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

A portrait of Alzheimer secretases--new features and familiar faces

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE)

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

A RIP tide in neuronal signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900188-6

7 January 2021

10.1016/S1474-4422(02)00188-6

Identifiers

DOI

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6 August 2017

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PubMed ID

12849363