Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex (Q35153371)

6 August 2017

Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex (English)

1 reference

6 August 2017

2

1 reference

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7 June 2020

author name string

Brian J Conti

1

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7 June 2020

Zhongying Yang

3

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7 June 2020

Ujwal Shinde

4

1 reference

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7 June 2020

William R Skach

5

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7 June 2020

publication date

23 February 2014

1 reference

Nature Structural & Molecular Biology

6 August 2017

1 reference

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7 June 2020

volume

21

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7 June 2020

issue

3

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7 June 2020

page(s)

228-235

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https://scigraph.springernature.com/pub.10.1038/nsmb.2779

7 June 2020

exact match

0 references

cites work

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Transmembrane segments form tertiary hairpins in the folding vestibule of the ribosome

13 July 2018

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Mechanisms of Sec61/SecY-mediated protein translocation across membranes

13 July 2018

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13 July 2018

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13 July 2018

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Membrane protein insertion at the endoplasmic reticulum

13 July 2018

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Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex

13 July 2018

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13 July 2018

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13 July 2018

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Probing the SecYEG translocation pore size with preproteins conjugated with sizable rigid spherical molecules

13 July 2018

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Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

13 July 2018

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Transient tertiary structure formation within the ribosome exit port

13 July 2018

1 reference

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Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

13 July 2018

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Cellular mechanisms of membrane protein folding

13 July 2018

1 reference

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The structural and functional coupling of two molecular machines, the ribosome and the translocon

13 July 2018

1 reference

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Translocation of proteins through the Sec61 and SecYEG channels

13 July 2018

1 reference

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The lateral gate of SecYEG opens during protein translocation

13 July 2018

1 reference

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Tertiary interactions within the ribosomal exit tunnel

13 July 2018

1 reference

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The concept of translocational regulation

13 July 2018

1 reference

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Biomimetic nanostructures: creating a high-affinity zinc-binding site in a folded nonbiological polymer

13 July 2018

1 reference

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Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia

13 July 2018

1 reference

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The efficiency of protein compartmentalization into the secretory pathway

13 July 2018

1 reference

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Structural insight into the protein translocation channel

13 July 2018

1 reference

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Complete sequencing and characterization of 21,243 full-length human cDNAs

13 July 2018

1 reference

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Sec61p contributes to signal sequence orientation according to the positive-inside rule

13 July 2018

1 reference

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X-ray structure of a protein-conducting channel

13 July 2018

1 reference

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Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequences

13 July 2018

1 reference

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The translocon: a dynamic gateway at the ER membrane

13 July 2018

1 reference

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A folding transition and novel zinc finger accessory domain in the transcription factor ADR1

13 July 2018

1 reference

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Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence.

13 July 2018

1 reference

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Transmembrane orientation of signal-anchor proteins is affected by the folding state but not the size of the N-terminal domain.

13 July 2018

1 reference

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Translocation can drive the unfolding of a preprotein domain.

13 July 2018

1 reference

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Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane

13 July 2018

1 reference

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Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore.

13 July 2018

1 reference

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Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes

13 July 2018

1 reference

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Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes

13 July 2018

1 reference

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Analysis of the distribution of charged residues in the N-terminal region of signal sequences: implications for protein export in prokaryotic and eukaryotic cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Sequences beyond the cleavage site influence signal peptide function.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Access of proteinase K to partially translocated nascent polypeptides in intact and detergent-solubilized membranes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Pause transfer: a topogenic sequence in apolipoprotein B mediates stopping and restarting of translocation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Dynamic switch of the signal recognition particle from scanning to targeting.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Folding zones inside the ribosomal exit tunnel

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Reticulocyte lysate as a model system to study endoplasmic reticulum membrane protein degradation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

On the competition for available zinc

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Protein folding during cotranslational translocation in the endoplasmic reticulum

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Signal sequences control gating of the protein translocation channel in a substrate-specific manner

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Translocational pausing is a common step in the biogenesis of unconventional integral membrane and secretory proteins.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Evidence for an alternate model of human P-glycoprotein structure and biogenesis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

The Geometry of the Ribosomal Polypeptide Exit Tunnel

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Combinatorial Control of Prion Protein Biogenesis by the Signal Sequence and Transmembrane Domain

8 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351553

Role of Sec61alpha in the regulated transfer of the ribosome-nascent chain complex from the signal recognition particle to the translocation channel

8 December 2018

1 reference

A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane

31 March 2020

1 reference

The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation

31 March 2020

1 reference

Uncoupling translocation from translation: implications for transport of proteins across membranes

31 March 2020

1 reference

Slow translocon gating causes cytosolic exposure of transmembrane and lumenal domains during membrane protein integration

31 March 2020

1 reference

Zinc-dependent structure of a single-finger domain of yeast ADR1

31 March 2020

1 reference

Kinetics of metal binding by a zinc finger peptide

31 March 2020

1 reference

Secondary structure formation of a transmembrane segment in Kv channels

31 March 2020

1 reference

Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration

31 March 2020

1 reference

A stop transfer sequence confers predictable transmembrane orientation to a previously secreted protein in cell-free systems

31 March 2020

1 reference

Positive charges on the translocating polypeptide chain arrest movement through the translocon

31 March 2020

1 reference

Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24561504

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.2779

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24561504%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24561504%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24561504%20AND%20SRC:MED&resulttype=core&format=json