X-ray structure of a protein-conducting channel (Q27642744)

Ian Collinson

3

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William M Clemons

William M Clemons

2

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Yorgo Modis

Yorgo Modis

4

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Stephen C. Harrison

6

Stephen C Harrison

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author name string

Bert Van den Berg

1

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Enno Hartmann

Protein translocation: tunnel vision

5

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language of work or name

English

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publication date

1 January 2004

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published in

Nature

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volume

427

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issue

6969

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page(s)

36-44

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

A protein-conducting channel in the endoplasmic reticulum.

21 January 2018

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Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore.

21 January 2018

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Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes

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The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation.

21 January 2018

1 reference

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Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane

21 January 2018

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Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex

21 January 2018

1 reference

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Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p

21 January 2018

1 reference

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BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase

21 January 2018

1 reference

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Post-translational secretion of fusion proteins in the halophilic archaea Haloferax volcanii.

21 January 2018

1 reference

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Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

21 January 2018

1 reference

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Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex

21 January 2018

1 reference

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The Structure of Ribosome-Channel Complexes Engaged in Protein Translocation

21 January 2018

1 reference

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Architecture of the protein-conducting channel associated with the translating 80S ribosome.

21 January 2018

1 reference

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Structure of the mammalian ribosome-channel complex at 17A resolution

21 January 2018

1 reference

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Three-dimensional structure of the bacterial protein-translocation complex SecYEG

21 January 2018

1 reference

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Structural determinants of water permeation through aquaporin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

Residues essential for the function of SecE, a membrane component of the Escherichia coli secretion apparatus, are located in a conserved cytoplasmic region

21 January 2018

1 reference

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Nearest neighbor analysis of the SecYEG complex. 2. Identification of a SecY-SecE cytosolic interface

21 January 2018

1 reference

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tRNA-mediated labelling of proteins with biotin. A nonradioactive method for the detection of cell-free translation products

21 January 2018

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Different conformations of nascent polypeptides during translocation across the ER membrane

21 January 2018

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Protein folding during cotranslational translocation in the endoplasmic reticulum

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Signal sequence recognition in posttranslational protein transport across the yeast ER membrane.

21 January 2018

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The sec and prl genes of Escherichia coli

21 January 2018

1 reference

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Role of the cytoplasmic segments of Sec61alpha in the ribosome-binding and translocation-promoting activities of the Sec61 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

The Sec protein-translocation pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

SecA protein is exposed to the periplasmic surface of the E. coli inner membrane in its active state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

Translocon pores in the endoplasmic reticulum are permeable to a neutral, polar molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

SecYEG assembles into a tetramer to form the active protein translocation channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

Fluorescence resonance energy transfer analysis of protein translocase. SecYE from Thermus thermophilus HB8 forms a constitutive oligomer in membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

Binding, activation and dissociation of the dimeric SecA ATPase at the dimeric SecYEG translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

SecY-SecY and SecY-SecG contacts revealed by site-specific crosslinking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

Evaluating the oligomeric state of SecYEG in preprotein translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

Mapping the sites of interaction between SecY and SecE by cysteine scanning mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

Inversion of the membrane topology of SecG coupled with SecA-dependent preprotein translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

7 January 2021

BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

7 January 2021

The aqueous pore through the translocon has a diameter of 40-60 A during cotranslational protein translocation at the ER membrane

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

7 January 2021

A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

7 January 2021

The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

7 January 2021

A signal sequence is not required for protein export in prlA mutants of Escherichia coli

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

7 January 2021

Cysteine-Directed Cross-Linking Demonstrates That Helix 3 of SecE Is Close to Helix 2 of SecY and Helix 3 of a Neighboring SecE†

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02218

7 January 2021

Identifiers

DOI

10.1038/NATURE02218

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

553552

1044275504

0 references

553552

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference