Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors (Q35146136)

6 August 2017

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title

Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors (English)

1 reference

6 August 2017

Wieslaw Kazmierski

1

1 reference

6 August 2017

Neil Bifulco

2

1 reference

6 August 2017

Hanbiao Yang

3

1 reference

6 August 2017

Larry Boone

4

1 reference

6 August 2017

Felix DeAnda

5

1 reference

6 August 2017

Chris Watson

6

1 reference

6 August 2017

Terry Kenakin

7

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6 August 2017

language of work or name

English

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publication date

1 July 2003

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Bioorganic & Medicinal Chemistry

6 August 2017

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6 August 2017

11

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6 August 2017

13

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6 August 2017

2663-2676

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Viral dynamics of HIV: implications for drug development and therapeutic strategies

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Antiretroviral therapy for HIV infection in 1998: updated recommendations of the International AIDS Society-USA Panel

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Primary HIV-1 resistance: a new phase in the epidemic?

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

HIV-1 protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Role of chemokine receptors in HIV-1 infection and pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Expression cloning of new receptors used by simian and human immunodeficiency viruses

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

CD4-independent infection by HIV-2 (ROD/B): use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Identification of a major co-receptor for primary isolates of HIV-1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Chemokine-leukocyte interactions. The voodoo that they do so well

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Chemokines--chemotactic cytokines that mediate inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

HIV blocked by chemokine antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Production of beta-chemokines in human immunodeficiency virus (HIV) infection: evidence that high levels of macrophage inflammatory protein-1beta are associated with a decreased risk of HIV disease progression

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Spontaneous and antigen-induced production of HIV-inhibitory beta-chemokines are associated with AIDS-free status

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Phenotypic knockout of HIV type 1 chemokine coreceptor CCR-5 by intrakines as potential therapeutic approach for HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Downregulation of the CCR5 beta-chemokine receptor and inhibition of HIV-1 infection by stable VA1-ribozyme chimeric transcripts

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Association of the CCR5delta32 mutation with improved response to antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

The CCR5Delta32 allele slows disease progression of human immunodeficiency virus-1-infected children receiving antiretroviral treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Co-receptor usage of HIV-1 primary isolates, viral burden, and CCR5 genotype in mother-to-child HIV-1 transmission

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Requirement of MIP-1 alpha for an inflammatory response to viral infection.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Resistance of primary isolates of human immunodeficiency virus type 1 to soluble CD4 is independent of CD4-rgp120 binding affinity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Association between CCR5 genotype and the clinical course of HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children. French Pediatric HIV Infection Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Genetic acceleration of AIDS progression by a promoter variant of CCR5.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS).

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Increased Replication of HIV-1 at Sites of Mycobacterium tuberculosis Infection: Potential Mechanisms of Viral Activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Chemokine receptors - the new frontier for AIDS research.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Determinants of entry cofactor utilization and tropism in a dualtropic human immunodeficiency virus type 1 primary isolate.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entry

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Proteins--paradigms of complex systems

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Conformational substates in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

The Energy Landscapes and Motions of Proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Molecular dynamics simulations in biology

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Structural mechanisms for domain movements in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Forces and factors that contribute to the structural stability of membrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Allosteric regulation of CCR5 by guanine nucleotides and HIV-1 envelope

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 in xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Receptor-mediated endocytosis of CC-chemokines

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Regulatory mechanisms that modulate signalling by G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Morphine activates opioid receptors without causing their rapid internalization

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

RANTES and MCP-3 antagonists bind multiple chemokine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Beyond receptor expression: the influence of receptor conformation, density, and affinity in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

A critical site in the core of the CCR5 chemokine receptor required for binding and infectivity of human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Chemokine expression in murine experimental allergic encephalomyelitis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

The viral envelope gene is involved in macrophage tropism of a human immunodeficiency virus type 1 strain isolated from brain tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Change in coreceptor use correlates with disease progression in HIV-1--infected individuals

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1alpha contains mutations in the envelope gp120 but does not show a switch in coreceptor use

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Viral phenotype and CCR5 genotype

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Enhancement of the HIV-1 inhibitory activity of RANTES by modification of the N-terminal region: dissociation from CCR5 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure-activity relationships for substituted 2-Aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. part 1: discovery and initial structure-activity relationships for 1 -amino-2-phenyl-4-(piperidin-1-yl)butanes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

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1 reference

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7 January 2021

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

1 reference

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7 January 2021

Combinatorial synthesis of CCR5 antagonists

1 reference

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7 January 2021

CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines

1 reference

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7 January 2021

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

1 reference

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7 January 2021

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailabl

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1 reference

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7 January 2021

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element

1 reference

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7 January 2021

Anti-human immunodeficiency virus interactions of SCH-C (SCH 351125), a CCR5 antagonist, with other antiretroviral agents in vitro

1 reference

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7 January 2021

Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.

1 reference

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Combined biophysical and biochemical information confirms arrangement of transmembrane helices visible from the three-dimensional map of frog rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900161-5

7 January 2021

10.1016/S0968-0896(03)00161-5

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DOI

1 reference

6 August 2017

1 reference