Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140 (Q28345395)

2

0 references

K A Nagashima

3

0 references

L Zhao

4

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T Cilliers

5

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L Morris

6

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J P Moore

7

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P J Maddon

8

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W C Olson

Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120

9

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language of work or name

English

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publication date

January 2001

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published in

Journal of Virology

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volume

75

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issue

2

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page(s)

579-88

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cites work

1 reference

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A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

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Variable sensitivity of CCR5-tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs

20 March 2017

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A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

20 March 2017

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Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression

20 March 2017

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Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

20 March 2017

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A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

20 March 2017

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Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

20 March 2017

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HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

7 April 2017

1 reference

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Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.

7 April 2017

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Coreceptor competition for association with CD4 may change the susceptibility of human cells to infection with T-tropic and macrophagetropic isolates of human immunodeficiency virus type 1

7 April 2017

1 reference

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Soluble complexes of regulated upon activation, normal T cells expressed and secreted (RANTES) and glycosaminoglycans suppress HIV-1 infection but do not induce Ca(2+) signaling

29 September 2017

1 reference

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Human immunodeficiency viruses in the developing world.

29 September 2017

1 reference

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Relationship between productive HIV-1 infection of macrophages and CCR5 utilization

29 September 2017

1 reference

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A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants

29 September 2017

1 reference

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Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates

29 September 2017

1 reference

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A cell line-based neutralization assay for primary human immunodeficiency virus type 1 isolates that use either the CCR5 or the CXCR4 coreceptor.

29 September 2017

1 reference

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Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo.

29 September 2017

1 reference

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Analysis of the critical domain in the V3 loop of human immunodeficiency virus type 1 gp120 involved in CCR5 utilization

29 September 2017

1 reference

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Adaptation to promiscuous usage of chemokine receptors is not a prerequisite for human immunodeficiency virus type 1 disease progression

29 September 2017

1 reference

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The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine

29 September 2017

1 reference

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The CC-chemokine RANTES increases the attachment of human immunodeficiency virus type 1 to target cells via glycosaminoglycans and also activates a signal transduction pathway that enhances viral infectivity

29 September 2017

1 reference

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Characterization of V3 sequence heterogeneity in subtype C human immunodeficiency virus type 1 isolates from Malawi: underrepresentation of X4 variants.

29 September 2017

1 reference

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Constitutive cell surface association between CD4 and CCR5.

29 September 2017

1 reference

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Phenotypic characteristics of human immunodeficiency virus type 1 subtype C isolates of Ethiopian AIDS patients

29 September 2017

1 reference

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Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5

29 September 2017

1 reference

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Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

29 September 2017

1 reference

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CCR5-Mediated human immunodeficiency virus entry depends on an amino-terminal gp120-binding site and on the conformational integrity of all four extracellular domains

29 September 2017

1 reference

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Enhancement of human immunodeficiency virus type 1 infection by the CC-chemokine RANTES is independent of the mechanism of virus-cell fusion

29 September 2017

1 reference

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Genetic acceleration of AIDS progression by a promoter variant of CCR5.

29 September 2017

1 reference

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Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro

29 September 2017

1 reference

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CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction

29 September 2017

1 reference

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Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application

29 September 2017

1 reference

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Expression of CCR5 increases during monocyte differentiation and directly mediates macrophage susceptibility to infection by human immunodeficiency virus type 1

29 September 2017

1 reference

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Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

29 September 2017

1 reference

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Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage- and dualtropic isolates of human immunodeficiency virus type 1.

29 September 2017

1 reference

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Differences in chemokine coreceptor usage between genetic subtypes of HIV-1.

29 September 2017

1 reference

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Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage.

29 September 2017

1 reference

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Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=113953

A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=113953

CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1

29 September 2017

1 reference

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Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines.

29 September 2017

1 reference

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Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=113953

Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=113953

Regulation of anti-HIV-1 activity of RANTES by heparan sulfate proteoglycans.

29 September 2017

1 reference

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Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

29 September 2017

1 reference

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Homozygous delta 32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient.

29 September 2017

1 reference

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CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro

29 September 2017

1 reference

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Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity

29 September 2017

1 reference

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Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

29 September 2017

1 reference

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The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression

29 September 2017

1 reference

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HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5.

29 September 2017

1 reference

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Change in coreceptor use correlates with disease progression in HIV-1--infected individuals

29 September 2017

1 reference

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Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=113953

CD8+ T-cell-derived soluble factor(s), but not beta-chemokines RANTES, MIP-1 alpha, and MIP-1 beta, suppress HIV-1 replication in monocyte/macrophages

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=113953

Strategies for AIDS vaccines

29 September 2017

1 reference

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Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques

29 September 2017

1 reference

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Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.

29 September 2017

1 reference

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Resistance of primary isolates of human immunodeficiency virus type 1 to soluble CD4 is independent of CD4-rgp120 binding affinity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=113953

The inhibitory effect of RANTES on the infection of primary macrophages by R5 human immunodeficiency virus type-1 depends on the macrophage activation state

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=113953

CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS).

2 June 2018

1 reference

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Synthetic full-length and truncated RANTES inhibit HIV-1 infection of primary macrophages.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=113953

Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines

2 June 2018

1 reference

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CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children. French Pediatric HIV Infection Study Group

2 June 2018

1 reference

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The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.

27 November 2018

1 reference

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HIV-1 entry inhibitors: evading the issue

27 November 2018

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12 December 2020

HIV-1 subtype C syncytium- and non-syncytium-inducing phenotypes and coreceptor usage among Ethiopian patients with AIDS

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12 December 2020

CC chemokine receptor 5 cell-surface expression in relation to CC chemokine receptor 5 genotype and the clinical course of HIV-1 infection

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12 December 2020

Beta-chemokine inhibition of monocytotropic HIV-1 infection. Interference with a postbinding fusion step

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12 December 2020

Chemokines and HIV replication

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12 December 2020

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

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12 December 2020

Fine definition of a conserved CCR5-binding region on the human immunodeficiency virus type 1 glycoprotein 120

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12 December 2020

HIV blocked by chemokine antagonist

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12 December 2020

HIV-1 infection in an individual homozygous for the CCR5 deletion allele

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12 December 2020

HIV-1 infection in a man homozygous for CCR5▵32

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12 December 2020

HIV-1 infection in an individual homozygous for CCR5 delta 32. Seroco Study Group

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12 December 2020

Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression

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12 December 2020

Association between CCR5 genotype and the clinical course of HIV-1 infection

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12 December 2020