Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. (Q35144590)

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7 February 2020

title

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination (English)

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7 February 2020

6

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Bernardo Reina San-Martin

7 February 2020

9

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7 February 2020

author name string

Beena Patricia Jeevan-Raj

1

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7 February 2020

Isabelle Robert

2

1 reference

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7 February 2020

Vincent Heyer

3

1 reference

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7 February 2020

Adeline Page

4

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7 February 2020

Jing H Wang

5

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7 February 2020

Frederick W Alt

7

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7 February 2020

Régine Losson

8

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7 February 2020

language of work or name

English

0 references

publication date

11 July 2011

1 reference

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Journal of Experimental Medicine

7 February 2020

published in

1 reference

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7 February 2020

volume

208

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7 February 2020

issue

8

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7 February 2020

page(s)

1649-1660

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Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

7 February 2020

cites work

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Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

13 July 2018

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Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5

13 July 2018

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14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.

13 July 2018

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Immunoglobulin class switch recombination deficiencies.

13 July 2018

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S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination

13 July 2018

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Ikaros controls isotype selection during immunoglobulin class switch recombination

13 July 2018

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Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

13 July 2018

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The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

13 July 2018

1 reference

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H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination

13 July 2018

1 reference

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Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination

13 July 2018

1 reference

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The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination

13 July 2018

1 reference

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Carboxy-terminal domain of AID required for its mRNA complex formation in vivo

13 July 2018

1 reference

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Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo

13 July 2018

1 reference

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AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations

13 July 2018

1 reference

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SHMTool: a webserver for comparative analysis of somatic hypermutation datasets

13 July 2018

1 reference

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Disruption of the interaction between transcriptional intermediary factor 1{beta} and heterochromatin protein 1 leads to a switch from DNA hyper- to hypomethylation and H3K9 to H3K27 trimethylation on the MEST promoter correlating with gene reactiva

13 July 2018

1 reference

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Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus

13 July 2018

1 reference

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RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

13 July 2018

1 reference

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S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase

13 July 2018

1 reference

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A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement

13 July 2018

1 reference

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IgH class switching and translocations use a robust non-classical end-joining pathway

13 July 2018

1 reference

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Evolution of the immunoglobulin heavy chain class switch recombination mechanism

13 July 2018

1 reference

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The role of activation-induced deaminase in antibody diversification and chromosome translocations

13 July 2018

1 reference

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Molecular mechanisms of antibody somatic hypermutation.

13 July 2018

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Heterochromatin revisited

13 July 2018

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The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression

13 July 2018

1 reference

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Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

13 July 2018

1 reference

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AID-dependent histone acetylation is detected in immunoglobulin S regions

13 July 2018

1 reference

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Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin

13 July 2018

1 reference

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The double-edged sword of activation-induced cytidine deaminase.

13 July 2018

1 reference

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ATM is required for efficient recombination between immunoglobulin switch regions

13 July 2018

1 reference

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Immunoglobulin class switch recombination is impaired in Atm-deficient mice

13 July 2018

1 reference

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Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation

13 July 2018

1 reference

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53BP1 is required for class switch recombination

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family

13 July 2018

1 reference

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Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice

13 July 2018

1 reference

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B lymphocyte-specific, Cre-mediated mutagenesis in mice

13 July 2018

1 reference

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H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

13 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110118

TIF1β association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110118

Separate domains of AID are required for somatic hypermutation and class-switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110118

AID mutant analyses indicate requirement for class-switch-specific cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110118

Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149220

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin κ-chain locus

27 September 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110118

Heterochromatin regulates cell type-specific long-range chromatin interactions essential for directed recombination

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21746811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Histone modifications associated with somatic hypermutation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21746811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21746811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20110118

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21746811%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21746811%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference