Separate domains of AID are required for somatic hypermutation and class-switch recombination (Q42828095)

8 November 2017

Separate domains of AID are required for somatic hypermutation and class-switch recombination (English)

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8 November 2017

9

Tasuku Honjo

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8 November 2017

5

Masamichi Muramatsu

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8 November 2017

Reiko Shinkura

1

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8 November 2017

Satomi Ito

2

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8 November 2017

Nasim A Begum

3

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8 November 2017

Hitoshi Nagaoka

4

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8 November 2017

Kazuo Kinoshita

6

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8 November 2017

Yoshimasa Sakakibara

7

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8 November 2017

Hiroko Hijikata

8

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8 November 2017

language of work or name

English

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publication date

13 June 2004

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8 November 2017

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8 November 2017

5

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8 November 2017

7

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8 November 2017

707-712

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Molecular mechanism of class switch recombination: linkage with somatic hypermutation

8 November 2017

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The mu switch region tandem repeats are important, but not required, for antibody class switch recombination

21 January 2018

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Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process

21 January 2018

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Both DNA strands of antibody genes are hypermutation targets

21 January 2018

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

21 January 2018

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The AID enzyme induces class switch recombination in fibroblasts

21 January 2018

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Somatic hypermutation of the AID transgene in B and non-B cells

21 January 2018

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Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

21 January 2018

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

21 January 2018

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De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

21 January 2018

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AID mediates hypermutation by deaminating single stranded DNA.

21 January 2018

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In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)

21 January 2018

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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

21 January 2018

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

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Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

21 January 2018

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

21 January 2018

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

21 January 2018

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Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

21 January 2018

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AID mutant analyses indicate requirement for class-switch-specific cofactors

21 January 2018

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C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

21 January 2018

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In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

21 January 2018

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Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

21 January 2018

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Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

21 January 2018

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Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

21 January 2018

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The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay

21 January 2018

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A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs

21 January 2018

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The influence of transcriptional orientation on endogenous switch region function

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NI1086

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8 November 2017

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