Contribution of stem cells and differentiated cells to epidermal tumours (Q35141779)

6 August 2017

1 reference

title

Contribution of stem cells and differentiated cells to epidermal tumours (English)

1 reference

6 August 2017

2

1 reference

6 August 2017

David M Owens

1

1 reference

PubMed ID

12778134

6 August 2017

language of work or name

English

0 references

publication date

1 June 2003

1 reference

6 August 2017

Nature Reviews Cancer

1 reference

6 August 2017

3

1 reference

6 August 2017

444-451

1 reference

6 August 2017

6

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc1096

6 August 2017

0 references

cites work

Stem cell fate and patterning in mammalian epidermis

1 reference

Designer skin: lineage commitment in postnatal epidermis

31 March 2020

1 reference

Involvement of follicular stem cells in forming not only the follicle but also the epidermis

31 March 2020

1 reference

Morphogenesis and renewal of hair follicles from adult multipotent stem cells

31 March 2020

1 reference

Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin

31 March 2020

1 reference

Epidermal stem cells: properties, markers, and location.

31 March 2020

1 reference

Three clonal types of keratinocyte with different capacities for multiplication

31 March 2020

1 reference

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

31 March 2020

1 reference

Stem cells, cancer, and cancer stem cells

31 March 2020

1 reference

The clonal evolution of tumor cell populations

31 March 2020

1 reference

Creation of human tumour cells with defined genetic elements

31 March 2020

1 reference

Rules for making human tumor cells

31 March 2020

1 reference

Frequent clones of p53-mutated keratinocytes in normal human skin

31 March 2020

1 reference

Sunlight and the onset of skin cancer

31 March 2020

1 reference

Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations

31 March 2020

1 reference

Stem-cell hierarchy in skin cancer

31 March 2020

1 reference

A multihit, multistage model of chemical carcinogenesis

31 March 2020

1 reference

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

31 March 2020

1 reference

Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene.

31 March 2020

1 reference

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

31 March 2020

1 reference

Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

31 March 2020

1 reference

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

31 March 2020

1 reference

c-Myc promotes differentiation of human epidermal stem cells

31 March 2020

1 reference

Deregulated expression of c-Myc depletes epidermal stem cells

31 March 2020

1 reference

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

31 March 2020

1 reference

A tumor-associated beta 1 integrin mutation that abrogates epithelial differentiation control

31 March 2020

1 reference

Role of integrins in regulating epidermal adhesion, growth and differentiation

31 March 2020

1 reference

Restoration of growth potential in paraclones of human keratinocytes by a viral oncogene

31 March 2020

1 reference

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

31 March 2020

1 reference

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia

31 March 2020

1 reference

c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin

31 March 2020

1 reference

Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease

31 March 2020

1 reference

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

31 March 2020

1 reference

TGF-beta antagonists: why suppress a tumor suppressor?

31 March 2020

1 reference

Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin

31 March 2020

1 reference

Sticky business: orchestrating cellular signals at adherens junctions

31 March 2020

1 reference

Perturbation in connexin 43 and connexin 26 gap-junction expression in mouse skin hyperplasia and neoplasia

31 March 2020

1 reference

Induction of skin papillomas, carcinomas, and sarcomas in mice in which the connexin 43 gene is heterologously deleted

31 March 2020

1 reference

A novel connexin 26 mutation in a patient diagnosed with keratitis-ichthyosis-deafness syndrome.

31 March 2020

1 reference

Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters.

31 March 2020

1 reference

Delta regulates keratinocyte spreading and motility independently of differentiation

31 March 2020

1 reference

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

31 March 2020

1 reference

Notch1 functions as a tumor suppressor in mouse skin

31 March 2020

1 reference

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

31 March 2020

1 reference

Basal cell carcinomas in mice overexpressing sonic hedgehog

31 March 2020

1 reference

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

31 March 2020

1 reference

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis

31 March 2020

1 reference

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development

31 March 2020

1 reference

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

31 March 2020

1 reference

p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes

31 March 2020

1 reference

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

31 March 2020

1 reference

Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation

31 March 2020

1 reference

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

31 March 2020

1 reference

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

31 March 2020

1 reference

Splitting hairs: dissecting roles of signaling systems in epidermal development

31 March 2020

1 reference

Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling

31 March 2020

1 reference

Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development

31 March 2020

1 reference

Hedgehog signalling in cancer

31 March 2020

1 reference

Activation of expression of hedgehog target genes in basal cell carcinomas

31 March 2020

1 reference

Basal cell carcinomas in mice overexpressing Gli2 in skin

31 March 2020

1 reference

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

31 March 2020

1 reference

Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

31 March 2020

1 reference

Activating Smoothened mutations in sporadic basal-cell carcinoma

31 March 2020

1 reference

PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer.

31 March 2020

1 reference

Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis

31 March 2020

1 reference

De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin

31 March 2020

1 reference

Links between signal transduction, transcription and adhesion in epithelial bud development

31 March 2020

1 reference

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

31 March 2020

1 reference

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin.

31 March 2020

1 reference

WNT signals are required for the initiation of hair follicle development

31 March 2020

1 reference

A common human skin tumour is caused by activating mutations in beta-catenin

31 March 2020

1 reference

Hedgehog signaling in animal development: paradigms and principles

31 March 2020

1 reference

The Hedgehog and Wnt signalling pathways in cancer

31 March 2020

1 reference

Wnt signals are targets and mediators of Gli function.

31 March 2020

1 reference

Prospective identification of tumorigenic breast cancer cells

31 March 2020

1 reference

Identification of the familial cylindromatosis tumour-suppressor gene

31 March 2020

1 reference

Muir-Torre-like syndrome in Fhit-deficient mice

31 March 2020

1 reference

"Second hit" in sebaceous tumors from Muir-Torre patients with germline mutations in MSH2: allele loss is not the preferred mode of inactivation

31 March 2020

1 reference

31 March 2020

1 reference

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1096

1 reference

6 August 2017

1 reference

PubMed ID

12778134