Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities (Q35074531)

6 August 2017

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title

Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities (English)

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6 August 2017

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Kevin D Niswender

1

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PubMed ID

12609497

6 August 2017

Michael W Schwartz

series ordinal

2

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6 August 2017

1 January 2003

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Frontiers in Neuroendocrinology

6 August 2017

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6 August 2017

24

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6 August 2017

1-10

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6 August 2017

1

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Acute third ventricular administration of insulin decreases food intake in two paradigms

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Short-Term Leptin-Dependent Inhibition of Hepatic Gluconeogenesis Is Mediated by Insulin Receptor Substrate-2

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Activation of downstream signals by the long form of the leptin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

The catabolic action of insulin in the brain is mediated by melanocortins.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Identification of binding sites for an insulin-like growth factor (IGF-I) in the median eminence of the rat brain by quantitative autoradiography

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Role of brain insulin receptor in control of body weight and reproduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

IRS-2 pathways integrate female reproduction and energy homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Modulation of insulin activities by leptin

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Selective deletion of leptin receptor in neurons leads to obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Molecular mechanisms involved in GLUT4 translocation in muscle during insulin and contraction stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Genetic analysis of insulin signaling in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Weight-reducing effects of the plasma protein encoded by the obese gene

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Essential role of phosphoinositide 3-kinase in leptin-induced K(ATP) channel activation in the rat CRI-G1 insulinoma cell line.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Hypoleptinemia, but not hypoinsulinemia, induces hyperphagia in streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

The role of depot fat in the hypothalamic control of food intake in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Clinical review 125: The insulin receptor and its cellular targets

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Prevention of fat-induced insulin resistance by salicylate

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Abnormal splicing of the leptin receptor in diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Action of insulin on the 'permeability' of cells to free hexoses, as studied by its effect on the distribution of galactose

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Localization of insulin receptor mRNA in rat brain by in situ hybridization

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

The continuing epidemics of obesity and diabetes in the United States

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Intracellular signalling. Key enzyme in leptin-induced anorexia

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Insulin signaling pathways in time and space.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Central nervous system control of food intake

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Cellular mechanisms of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Low plasma leptin levels contribute to diabetic hyperphagia in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Effects of leptin on insulin sensitivity in normal rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Obesity and the regulation of energy balance

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

The role of neuropeptide Y in the antiobesity action of the obese gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Insulin responses and glucose levels in plasma and cerebrospinal fluid during fasting and refeeding in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Cerebrospinal fluid insulin levels increase during intravenous insulin infusions in man

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Recombinant ob protein reduces feeding and body weight in the ob/ob mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Positional cloning of the mouse obese gene and its human homologue

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia

1 reference

https://api.crossref.org/works/10.1016%2FS0091-3022%2802%2900105-X

7 January 2021

10.1016/S0091-3022(02)00105-X

Identifiers

DOI

1 reference

release_mmzckm55kzgthd7hdga5sodeha

6 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mmzckm55kzgthd7hdga5sodeha

24 November 2022

mapped directly with Wikidata item

PubMed ID

12609497

1 reference

PubMed ID

12609497