Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. (Q35054990)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25495872%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop (English)

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24 February 2020

4

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24 February 2020

David Mangelsdorf

8

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24 February 2020

Carolyn L. Cummins

10

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24 February 2020

author name string

Rucha Patel

1

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24 February 2020

Angie L Bookout

2

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24 February 2020

Lilia Magomedova

3

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24 February 2020

Giulia P Consiglio

5

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24 February 2020

Makoto Shimizu

6

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24 February 2020

Yuan Zhang

7

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24 February 2020

Steven A Kliewer

9

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24 February 2020

publication date

11 December 2014

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24 February 2020

published in

Molecular Endocrinology

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24 February 2020

volume

29

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issue

2

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page(s)

213-223

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describes a project that uses

24 February 2020

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4318881/fullTextXML

inferred from PubMed Central ID database lookup

cites work

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.

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FGF21 regulates metabolism and circadian behavior by acting on the nervous system

8 July 2018

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Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding.

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Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo

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FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

8 July 2018

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Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

8 July 2018

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FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho

8 July 2018

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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25 October 2018

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Growth hormone stimulates transcription of the fibroblast growth factor 21 gene in the liver through the signal transducer and activator of transcription 5.

25 October 2018

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Liver upregulation of genes involved in cortisol production and action is associated with metabolic syndrome in morbidly obese patients.

25 October 2018

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Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers.

25 October 2018

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Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans.

25 October 2018

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Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride

25 October 2018

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25 October 2018

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Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity.

25 October 2018

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Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

25 October 2018

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Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice

25 October 2018

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Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes.

25 October 2018

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Lack of decrease in hypothalamic and hippocampal glucocorticoid receptor mRNA during starvation

25 October 2018

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Effect of adrenalectomy on the metabolism of glucose in obese (C57 Bl/6J ob/ob) mice.

25 October 2018

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25 October 2018

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12 December 2020

Adrenalectomy reverses insulin resistance in muscle from obese (ob/ob) mice

1 reference

12 December 2020

The effect of splanchnic nerve section on the sensitivity of the adrenal cortex to adrenocorticotrophin in the calf

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12 December 2020

Expression of the Peroxisome Proliferator-activated Receptor Gene Is Stimulated by Stress and Follows a Diurnal Rhythm

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12 December 2020

High-throughput real-time quantitative reverse transcription PCR

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12 December 2020

Identifiers

DOI

10.1210/ME.2014-1259

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25495872%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25495872%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25495872

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25495872%20AND%20SRC:MED&resulttype=core&format=json