LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. (Q34428893)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21123945%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice (English)

1 reference

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17 January 2020

1 reference

11

1 reference

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17 January 2020

Carolyn L. Cummins

12

1 reference

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17 January 2020

author name string

Rucha Patel

1

1 reference

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17 January 2020

Monika Patel

2

1 reference

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17 January 2020

Ricky Tsai

3

1 reference

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17 January 2020

Vicky Lin

4

1 reference

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17 January 2020

Angie L Bookout

5

1 reference

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17 January 2020

Yuan Zhang

6

1 reference

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17 January 2020

Lilia Magomedova

7

1 reference

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17 January 2020

Tingting Li

8

1 reference

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17 January 2020

Jessica F Chan

9

1 reference

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17 January 2020

Conrad Budd

10

1 reference

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17 January 2020

language of work or name

English

0 references

publication date

1 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21123945%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

17 January 2020

published in

1 reference

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17 January 2020

volume

121

1 reference

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17 January 2020

issue

1

1 reference

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17 January 2020

page(s)

431-441

1 reference

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describes a project that uses

17 January 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3007136/fullTextXML

inferred from PubMed Central ID database lookup

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Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice

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Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C

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The search for safer glucocorticoid receptor ligands

6 July 2018

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LXR-dependent gene expression is important for macrophage survival and the innate immune response

6 July 2018

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Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

6 July 2018

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A simple method for the isolation and purification of total lipides from animal tissues

6 July 2018

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Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha

6 July 2018

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Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

6 July 2018

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Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

6 July 2018

1 reference

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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

6 July 2018

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Mechanisms involved in the side effects of glucocorticoids

6 July 2018

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Glucocorticoid metabolism and the Metabolic Syndrome: associations in an elderly cohort

6 July 2018

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Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

6 July 2018

1 reference

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Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

6 July 2018

1 reference

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The glucose-6-phosphatase system

6 July 2018

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Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis

6 July 2018

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Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

6 July 2018

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Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice

6 July 2018

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Tissue-specific dysregulation of cortisol metabolism in human obesity

6 July 2018

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Impaired glucose tolerance and elevated blood pressure in low birth weight, nonobese, young south african adults: early programming of cortisol axis

6 July 2018

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Role of LXRs in control of lipogenesis

6 July 2018

1 reference

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

6 July 2018

1 reference

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The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

6 July 2018

1 reference

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Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction

6 July 2018

1 reference

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The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

6 July 2018

1 reference

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Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor

6 July 2018

1 reference

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Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

6 July 2018

1 reference

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Glucocorticoids and muscle catabolism

6 July 2018

1 reference

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Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids.

6 July 2018

1 reference

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Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

6 July 2018

1 reference

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Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

6 July 2018

1 reference

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An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

6 July 2018

1 reference

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Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids

6 July 2018

1 reference

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Effects of glucocorticoids on carbohydrate metabolism

6 July 2018

1 reference

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Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP)

6 July 2018

1 reference

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The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Modulation of the Activity of Insulin-Dependent Enzymes of Lipogenesis by Glucocorticoids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome

27 October 2018

1 reference

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Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

LXRs regulate the balance between fat storage and oxidation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Visceral fat and liver fat are independent predictors of metabolic risk factors in men.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Fat distribution in obese women is associated with subtle alterations of the hypothalamic-pituitary-adrenal axis activity and sensitivity to glucocorticoids

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007136

Association of nonalcoholic fatty liver disease with insulin resistance.

27 October 2018

1 reference

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Stimulation of lipolysis in humans by physiological hypercortisolemia

27 October 2018

1 reference

12 December 2020

Involvement of non-esterified fatty acid oxidation in glucocorticoid-induced peripheral insulin resistance in vivo in rats

1 reference

12 December 2020

High-throughput real-time quantitative reverse transcription PCR

1 reference

12 December 2020

1 reference

12 December 2020

The synergistic effect of cortisone and insulin on lipogenesis in the perfused rat liver as studied with alpha-C14-acetate

1 reference

12 December 2020

Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid beta-oxidation

1 reference

12 December 2020

Dexamethasone inhibits insulin-stimulated recruitment of GLUT4 to the cell surface in rat skeletal muscle

1 reference

12 December 2020

The Phosphoenolpyruvate Carboxykinase Gene Glucocorticoid Response Unit: Identification of the Functional Domains of Accessory Factors HNF3β (Hepatic Nuclear Factor-3β) and HNF4 and the Necessity of Proper Alignment of Their Cognate Binding Sites

1 reference

12 December 2020

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12 December 2020

Transcription activation of the tyrosine aminotransferase gene by glucocorticoids and cAMP in primary hepatocytes

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI41681

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21123945%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21123945%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference