Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies. (Q35049310)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12537515%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

review article

1 reference

title

Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12537515%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12537515%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

José V Castell

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12537515%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

author name string

M Teresa Donato

series ordinal

1

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6 August 2017

José V Castell

series ordinal

2

1 reference

6 August 2017

1 January 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12537515%20AND%20SRC:MED&resulttype=core&format=json

Clinical Pharmacokinetics

17 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12537515%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

volume

42

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12537515%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

page(s)

153-178

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17 December 2019

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12537515%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.2165/00003088-200342020-00004

17 December 2019

exact match

0 references

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Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

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Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism.

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Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers

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Nifedipine: variability in its kinetics and metabolism in man.

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Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men

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Metoprolol metabolism and debrisoquine oxidation polymorphism--population and family studies

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Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylainine to products genotoxic in an acetyltransferase–overexpressing Salmonella typhimurium strain (NM2009)

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Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)

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Validation and use of cloned, expressed human drug-metabolizing enzymes in heterologous cells for analysis of drug metabolism and drug-drug interactions

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Co-regulation of phenytoin and tolbutamide metabolism in humans

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Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs

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Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

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Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology

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Use of a novel real-time quantitative reverse transcription-polymerase chain reaction method to study the effects of cytokines on cytochrome P450 mRNA expression in mouse liver

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12 December 2020

Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans

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12 December 2020

Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.

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12 December 2020