Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement. (Q35031537)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25561522%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

title

Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25561522%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

2

1 reference

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27 February 2020

6

James M Berger

1 reference

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27 February 2020

7

Michael R Botchan

1 reference

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27 February 2020

author name string

Tatjana Petojevic

1

1 reference

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27 February 2020

Alessandro Costa

3

1 reference

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27 February 2020

Jingdan Liang

4

1 reference

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27 February 2020

Zhijun Wang

5

1 reference

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27 February 2020

language of work or name

English

0 references

publication date

5 January 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25561522%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

27 February 2020

published in

1 reference

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27 February 2020

volume

112

1 reference

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27 February 2020

issue

3

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27 February 2020

page(s)

E249-58

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Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function

27 February 2020

cites work

1 reference

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CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication.

8 July 2018

1 reference

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Analysis of the crystal structure of an active MCM hexamer

8 July 2018

1 reference

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DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.

8 July 2018

1 reference

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Multiple functions for Mcm2-7 ATPase motifs during replication initiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase

8 July 2018

1 reference

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A conserved MCM single-stranded DNA binding element is essential for replication initiation

8 July 2018

1 reference

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The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro

8 July 2018

1 reference

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DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

The minichromosome maintenance replicative helicase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

RecJ-like protein from Pyrococcus furiosus has 3'-5' exonuclease activity on RNA: implications for proofreading of 3'-mismatched RNA primers in DNA replication.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

A novel DNA nuclease is stimulated by association with the GINS complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

The Mcm2-7 complex has in vitro helicase activity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Cryo-electron microscopy reveals a novel DNA-binding site on the MCM helicase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Molecular architecture of the human GINS complex.

8 July 2018

1 reference

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Cdc45-MCM-GINS, a new power player for DNA replication.

8 July 2018

1 reference

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Mechanism of DNA translocation in a replicative hexameric helicase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

GINS, a central nexus in the archaeal DNA replication fork

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

FFAS03: a server for profile--profile sequence alignments

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Oxidative DNA damage and disease: induction, repair and significance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Thymine-rich single-stranded DNA activates Mcm4/6/7 helicase on Y-fork and bubble-like substrates

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311868

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422003112

Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422003112

MCM forked substrate specificity involves dynamic interaction with the 5'-tail.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422003112

Cdc45: the missing RecJ ortholog in eukaryotes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422003112

Hydroxyl radical-induced cross-linking of thymine and lysine: identification of the primary structure and mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422003112

Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422003112

Prereplication-complex formation: a molecular double take?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422003112

Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25561522

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12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1422003112

1 reference

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27 February 2020

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release_pmogl3ar3vew3fjwjhy64ogqdu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pmogl3ar3vew3fjwjhy64ogqdu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25561522%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25561522%20AND%20SRC:MED&resulttype=core&format=json