Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1. (Q35031314)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24188018%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1 (English)

1 reference

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29 February 2020

1 reference

3

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29 February 2020

Steven Zimmerman

7

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29 February 2020

author name string

Amin Haghighat Jahromi

1

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29 February 2020

Yuan Fu

2

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29 February 2020

Lien Nguyen

4

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29 February 2020

Long M Luu

5

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29 February 2020

Anne M Baranger

6

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29 February 2020

language of work or name

English

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publication date

21 November 2013

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Journal of Medicinal Chemistry

29 February 2020

published in

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29 February 2020

volume

56

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29 February 2020

issue

23

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29 February 2020

page(s)

9471-9481

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Threading polyintercalators with extremely slow dissociation rates and extended DNA binding sites

29 February 2020

cites work

1 reference

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Single-molecule study of the CUG repeat-MBNL1 interaction and its inhibition by small molecules.

8 July 2018

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A novel CUG(exp)·MBNL1 inhibitor with therapeutic potential for myotonic dystrophy type 1.

8 July 2018

1 reference

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RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy

8 July 2018

1 reference

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Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder

8 July 2018

1 reference

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Targeting nuclear RNA for in vivo correction of myotonic dystrophy

8 July 2018

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From dynamic combinatorial 'hit' to lead: in vitro and in vivo activity of compounds targeting the pathogenic RNAs that cause myotonic dystrophy

8 July 2018

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Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

8 July 2018

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RNA-binding proteins in microsatellite expansion disorders: mediators of RNA toxicity

8 July 2018

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RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1

8 July 2018

1 reference

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Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive

8 July 2018

1 reference

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Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching

8 July 2018

1 reference

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New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats

8 July 2018

1 reference

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Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents.

8 July 2018

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MBNL1-RNA recognition: contributions of MBNL1 sequence and RNA conformation

8 July 2018

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RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2

8 July 2018

1 reference

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Using modularly assembled ligands to bind RNA internal loops separated by different distances

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Therapeutics development in myotonic dystrophy type 1.

8 July 2018

1 reference

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Design strategies for bivalent ligands targeting GPCRs

8 July 2018

1 reference

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Identification of MBNL1 and MBNL3 domains required for splicing activation and repression

8 July 2018

1 reference

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Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor.

8 July 2018

1 reference

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CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1.

8 July 2018

1 reference

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Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists

8 July 2018

1 reference

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Molecular therapy in myotonic dystrophy: focus on RNA gain-of-function

8 July 2018

1 reference

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Pathogenic mechanisms of myotonic dystrophy

8 July 2018

1 reference

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Chemical reversal of the RNA gain of function in myotonic dystrophy

8 July 2018

1 reference

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Pentamidine reverses the splicing defects associated with myotonic dystrophy.

8 July 2018

1 reference

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A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding.

8 July 2018

1 reference

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Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA.

8 July 2018

1 reference

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Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

8 July 2018

1 reference

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Structural insights into CUG repeats containing the 'stretched U-U wobble': implications for myotonic dystrophy

8 July 2018

1 reference

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Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2.

8 July 2018

1 reference

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Mechanisms of RNA-mediated disease.

8 July 2018

1 reference

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The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: implications for myotonic dystrophy

8 July 2018

1 reference

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Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation

8 July 2018

1 reference

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Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

A detergent-based assay for the detection of promiscuous inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

The structural basis of myotonic dystrophy from the crystal structure of CUG repeats

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

On the nature of the multivalency effect: a thermodynamic model

8 July 2018

1 reference

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A muscleblind knockout model for myotonic dystrophy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Preparation of Discrete Oligoethers: Synthesis of Pentabutylene Glycol and Hexapropylene Glycol by Two Complementary Methods

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Acridine derivatives as chemotherapeutic agents

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Fluorescence characteristics of 5-carboxytetramethylrhodamine linked covalently to the 5' end of oligonucleotides: multiple conformers of single-stranded and double-stranded dye-DNA complexes

8 July 2018

1 reference

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Polyacrylamides bearing pendant alpha-sialoside groups strongly inhibit agglutination of erythrocytes by influenza A virus: multivalency and steric stabilization of particulate biological systems

8 July 2018

1 reference

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Polyfunctional DNA intercalating agents

8 July 2018

1 reference

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Interaction of a macrocyclic bisacridine with DNA.

8 July 2018

1 reference

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The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H₂ receptor agonists

8 July 2018

1 reference

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Development of a bivalent dopamine D₂ receptor agonist

25 October 2018

1 reference

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Bivalent dopamine D2 receptor ligands: synthesis and binding properties.

25 October 2018

1 reference

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Synthesis of linear polyamines with different amine spacings and their ability to form dsDNA/siRNA complexes suitable for transfection.

25 October 2018

1 reference

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The influence of rigid or flexible linkage between two ligands on the effective affinity and avidity for reversible interactions with bivalent receptors.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Sulforhodamine B colorimetric assay for cytotoxicity screening.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Design of a sequence-specific DNA bisintercalator

25 October 2018

1 reference

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Dimeric aminoglycosides as antibiotics.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agents

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925341

Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture

25 October 2018

1 reference

12 December 2020

Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity

1 reference

12 December 2020

A reversal of misfortune for myotonic dystrophy?

1 reference

12 December 2020

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

1 reference

12 December 2020

Calculation of binding isotherms for heterogeneous polymers

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM400794Z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24188018%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24188018%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

24188018

1 reference