Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching (Q34149072)

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English	Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching	scientific article

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scholarly article

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Europe PubMed Central

31 July 2017

Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching (English)

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Europe PubMed Central

31 July 2017

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myotonic dystrophy

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based on heuristic

inferred from title

7

object named as

Jason Hoskins

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Europe PubMed Central

31 July 2017

author name string

Raman Parkesh

1

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Europe PubMed Central

31 July 2017

Jessica L Childs-Disney

2

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Europe PubMed Central

31 July 2017

Masayuki Nakamori

3

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Europe PubMed Central

31 July 2017

Amit Kumar

4

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Europe PubMed Central

31 July 2017

Eric Wang

5

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Europe PubMed Central

31 July 2017

Thomas Wang

6

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31 July 2017

Tuan Tran

8

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Europe PubMed Central

31 July 2017

David Housman

9

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Europe PubMed Central

31 July 2017

Charles A Thornton

10

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Europe PubMed Central

31 July 2017

Matthew D Disney

11

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31 July 2017

language of work or name

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publication date

5 March 2012

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31 July 2017

Journal of the American Chemical Society

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31 July 2017

134

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31 July 2017

10

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Europe PubMed Central

31 July 2017

4731-4742

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Europe PubMed Central

31 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3306011/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

CAG repeats mimic CUG repeats in the misregulation of alternative splicing

1 reference

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Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy

1 reference

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5 July 2018

Pentamidine reverses the splicing defects associated with myotonic dystrophy.

1 reference

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5 July 2018

A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding.

1 reference

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5 July 2018

Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy.

1 reference

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Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA.

1 reference

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5 July 2018

Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

1 reference

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5 July 2018

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations

1 reference

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5 July 2018

Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1).

1 reference

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5 July 2018

Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay

1 reference

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5 July 2018

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

1 reference

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5 July 2018

MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Using selection to identify and chemical microarray to study the RNA internal loops recognized by 6'-N-acylated kanamycin A.

1 reference

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5 July 2018

Aminoglycosides and other factors promoting stop codon readthrough in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

A bichromatic fluorescent reporter for cell-based screens of alternative splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

MicroRNAs and chromosomal abnormalities in cancer cells

1 reference

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5 July 2018

Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy

1 reference

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5 July 2018

RNA-mediated neuromuscular disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Small molecule shape-fingerprints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Alterations of pre-mRNA splicing in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Muscleblind proteins regulate alternative splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

A muscleblind knockout model for myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Pre-mRNA splicing and human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

An extensive class of small RNAs in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Identification of novel genes coding for small expressed RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

The binding site of a specific aminoglycoside binding RNA molecule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Three-dimensional hydrogen-bond geometry and probability information from a crystal survey

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Directing alternative splicing: cast and scenarios

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Triplet repeat mutations in human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

An unstable triplet repeat in a gene related to myotonic muscular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

5 July 2018

Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

28 October 2018

Molecular architecture of CAG repeats in human disease related transcripts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

28 October 2018

Expression of MBNL and CELF mRNA transcripts in muscles with myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306011

28 October 2018

Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22300544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22300544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing the performance of OMEGA with respect to retrieving bioactive conformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/22300544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22300544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/22300544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear RNA foci in the heart in myotonic dystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22300544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/22300544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Do structurally similar ligands bind in a similar fashion?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22300544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA210088V

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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