Homologous repair of DNA damage and tumorigenesis: the BRCA connection (Q35026393)

5 August 2017

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title

Homologous repair of DNA damage and tumorigenesis: the BRCA connection (English)

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5 August 2017

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Maria Jasin

1

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PubMed ID

12483514

5 August 2017

language of work or name

English

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publication date

1 December 2002

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5 August 2017

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5 August 2017

21

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5 August 2017

8981-8993

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5 August 2017

58

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1206176

5 August 2017

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cites work

A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

The human Rad51 protein: polarity of strand transfer and stimulation by hRP-A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

DNA end-joining catalyzed by human cell-free extracts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

On the use of familial aggregation in population-based case probands for calculating penetrance.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Internal repeats in the BRCA2 protein sequence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

The importance of repairing stalled replication forks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA1 supports XIST RNA concentration on the inactive X chromosome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Assembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA1 required for transcription-coupled repair of oxidative DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

The many interfaces of Mre11

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA1 protein products ... Functional motifs...

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Deficiency in BRCA2 leads to increase in non-conservative homologous recombination.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Identification and preliminary characterization of a protein motif related to the zinc finger

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Tumorigenesis in mice carrying a truncating Brca1 mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Brca1 required for T cell lineage development but not TCR loci rearrangement.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA1: exploring the links to transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Brca1 controls homology-directed DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA2 is required for homology-directed repair of chromosomal breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Nine novel conserved motifs in BRCA1 identified by the chicken orthologue.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Involvement of Brca2 in DNA repair

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

New glimpses of an old machine

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Direct DNA binding by Brca1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Identification of a functional nuclear export sequence in BRCA1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA1 is a cell cycle-regulated nuclear phosphoprotein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Association of BRCA1 with Rad51 in mitotic and meiotic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Genetic analysis of BRCA1 function in a defined tumor cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

In search of the tumour-suppressor functions of BRCA1 and BRCA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Murine Brca2: sequence, map position, and expression pattern.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Brca2 is required for embryonic cellular proliferation in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Conserved domains in the chicken homologue of BRCA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Chromosomal stability and the DNA double-stranded break connection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

53BP1, a mediator of the DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Insights into the functions of BRCA1 and BRCA2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing feature

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Nuclear localization signals of the BRCA2 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206176

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206176

1 reference

5 August 2017

1 reference

PubMed ID

12483514