A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding (Q35016200)

5 August 2017

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title

A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding (English)

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5 August 2017

2

Antonio Lanzavecchia

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5 August 2017

Jacob Rachmilewitz

1

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5 August 2017

1 December 2002

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5 August 2017

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5 August 2017

23

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5 August 2017

12

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5 August 2017

592-595

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Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

The minimal number of class II MHC-antigen complexes needed for T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Kinetics and extent of protein tyrosine kinase activation in individual T cells upon antigenic stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Three-dimensional segregation of supramolecular activation clusters in T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Kinetics and extent of T cell activation as measured with the calcium signal

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Mapping the sensitivity of T cells with an optical trap: polarity and minimal number of receptors for Ca(2+) signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Serial triggering of T cell receptors results in incremental accumulation of signaling intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

T lymphocyte costimulation mediated by reorganization of membrane microdomains

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

A receptor/cytoskeletal movement triggered by costimulation during T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

The immunological synapse and CD28-CD80 interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Antigen decoding by T lymphocytes: from synapses to fate determination

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

T cell activation determined by T cell receptor number and tunable thresholds.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

The duration of antigenic stimulation determines the fate of naive and effector T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Understanding the mechanisms of sustained signaling and T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Calcium oscillations increase the efficiency and specificity of gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

Self-help in T cell recognition?

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4906%2802%2902342-6

7 January 2021

10.1016/S1471-4906(02)02342-6

Identifiers

DOI

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5 August 2017

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PubMed ID

12464571