Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation. (Q35013689)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21272640%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

review article

1 reference

title

Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21272640%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21272640%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

author name string

Trevor M Penning

series ordinal

1

1 reference

5 August 2017

25 January 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21272640%20AND%20SRC:MED&resulttype=core&format=json

The Journal of Steroid Biochemistry and Molecular Biology

21 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21272640%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

volume

125

1 reference

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21 January 2020

issue

1-2

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21 January 2020

page(s)

46-56

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Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening.

21 January 2020

cites work

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8 July 2018

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The kinetic mechanism catalysed by homogeneous rat liver 3 alpha-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs

8 July 2018

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Structure of the Human Type II 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4Isomerase (3β-HSD) Gene: Adrenal and Gonadal Specificity

8 July 2018

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Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11β-hydroxysteroid dehydrogenase type 2.

8 July 2018

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Selective inhibition of the tumor marker AKR1B10 by antiinflammatory N-phenylanthranilic acids and glycyrrhetic acid

25 October 2018

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Novel estrone mimetics with high 17beta-HSD1 inhibitory activity

25 October 2018

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Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors

25 October 2018

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New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity

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Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1).

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104102

The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-Hydroxysteroid Dehydrogenase (17beta-HSD) type 1 and type 2.

25 October 2018

1 reference

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Discovery of new inhibitors of aldo-keto reductase 1C1 by structure-based virtual screening

25 October 2018

1 reference

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Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104102

4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104102

Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent d

25 October 2018

1 reference

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Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.

25 October 2018

1 reference

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Arginine 276 controls the directional preference of AKR1C9 (rat liver 3alpha-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells

25 October 2018

1 reference

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Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease

25 October 2018

1 reference

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Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104102

Transient-phase kinetic studies on the nucleotide binding to 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831 using fluorescence stopped-flow procedures

25 October 2018

1 reference

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Human aldose reductase: pK of tyrosine 48 reveals the preferred ionization state for catalysis and inhibition

25 October 2018

1 reference

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Secosteroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3 alpha-hydroxysteroid dehydrogenase

25 October 2018

1 reference

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17Beta-hydroxysteroid dehydrogenase from Cochliobolus lunatus: model structure and substrate specificity

25 October 2018

1 reference

12 December 2020

Mechanism-based inactivation of 17 beta,20 alpha-hydroxysteroid dehydrogenase by an acetylenic secoestradiol

1 reference

12 December 2020

Characterization of the structure-activity relationships of rat types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5 -delta 4 isomerase by site-directed mutagenesis and expression in HeLa cells

1 reference

12 December 2020

Clues to the development of mechanism-based inactivators of 3 alpha-hydroxysteroid dehydrogenase: comparison of steroidal and nonsteroidal Michael acceptors and epoxides

1 reference

12 December 2020

Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma

1 reference

12 December 2020

Assay optimization and kinetic profile of the human and the rabbit isoforms of 11beta-HSD1

1 reference

12 December 2020

Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9)

1 reference

12 December 2020

An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone

1 reference

12 December 2020

The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase

1 reference

12 December 2020

The enzymatic transfer of hydrogen. I. The reaction catalyzed by alcohol dehydrogenase

1 reference

12 December 2020

The enzymatic transfer of hydrogen. II. The reaction catalyzed by lactic dehydrogenase

1 reference

12 December 2020

Siet specificity and mechanism of human placental 17-beta-hydroxysteroid dehydrogenase

1 reference

12 December 2020

Stereochemistry of hydrogen transfer by rat ovary 20 alpha-hydroxysteroid dehydrogenase

1 reference

12 December 2020

["Intracrinology". Autonomy and freedom of peripheral tissues]

1 reference

12 December 2020

17 beta-hydroxysteroid dehydrogenase: isozymes and mutations

1 reference

12 December 2020

10.1016/J.JSBMB.2011.01.009

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21272640%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21272640%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference