Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo. (Q35012724)

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English	Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo.	scientific article

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scholarly article

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19 January 2020

Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo (English)

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19 January 2020

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based on heuristic

inferred from title

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based on heuristic

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ductal carcinoma

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inferred from title

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Fredrik Wärnberg

1

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19 January 2020

Robert B. Clarke

5

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19 January 2020

author name string

Daniel White

2

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19 January 2020

Elizabeth Anderson

3

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19 January 2020

Fiona Knox

4

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19 January 2020

Julie Morris

6

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19 January 2020

Nigel J Bundred

7

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19 January 2020

publication date

12 April 2006

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19 January 2020

Breast Cancer Research

1 reference

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19 January 2020

8

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19 January 2020

2

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19 January 2020

R21

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19 January 2020

https://scigraph.springernature.com/pub.10.1186/bcr1395

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Recent advances in understanding the antineoplastic mechanisms of farnesyltransferase inhibitors

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8 July 2018

Development of farnesyl transferase inhibitors: a review

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8 July 2018

The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro

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8 July 2018

Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557711

8 July 2018

Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancer

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8 July 2018

Breast cancer endocrine resistance: how growth factor signaling and estrogen receptor coregulators modulate response.

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8 July 2018

Targeting RAS signalling pathways in cancer therapy

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8 July 2018

Farnesyltransferase inhibitors in breast cancer therapy

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8 July 2018

Inhibitors of protein farnesyltransferase as novel anticancer agents

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8 July 2018

Current progress on farnesyl protein transferase inhibitors

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8 July 2018

Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival

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8 July 2018

A formalin-fixed, paraffin-processed cell line standard for quality control of immunohistochemical assay of HER-2/neu expression in breast cancer

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8 July 2018

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models

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8 July 2018

Tumour markers in breast carcinoma correlate with grade rather than with invasiveness

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8 July 2018

The ras signaling pathway in mammary tumorigenesis and metastasis.

1 reference

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8 July 2018

In vivo cell kinetics in breast carcinogenesis

1 reference

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8 July 2018

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

1 reference

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8 July 2018

Signal transduction in mammary tumorigenesis: a transgenic perspective

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8 July 2018

Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway

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8 July 2018

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

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8 July 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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8 July 2018

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

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8 July 2018

Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu

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8 July 2018

Aberrant function of the Ras signal transduction pathway in human breast cancer

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8 July 2018

ras oncogenes in human cancer: a review

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8 July 2018

Apoptosis in ductal carcinoma in situ of the breast

1 reference

https://api.crossref.org/works/10.1186%2FBCR1395

21 January 2018

Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignancies

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21 January 2018

Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer

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21 January 2018

Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.

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25 October 2018

Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.

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25 October 2018

Expression of c-erbB receptors, heregulin and oestrogen receptor in human breast cell lines

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21 January 2018

Differential expression and mutation of the ras family genes in human breast cancer

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21 January 2018

The use of molecular markers in farnesyltransferase inhibitor (FTI) therapy of breast cancer

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Assessment of Hormone Dependence of Comedo Ductal Carcinoma In Situ of the Breast

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21 January 2018

Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer

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21 January 2018

Apoptosis occurs more frequently in intraductal carcinoma than in infiltrating duct carcinoma of human breast cancer and correlates with altered p53 expression: detected by terminal-deoxynucleotidyl-transferase-mediated dUTP-FITC nick end labelling

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21 January 2018

Molecular characterization of intraductal breast carcinomas

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21 January 2018

Association between the ras p21 oncoprotein in blood samples and breast cancer

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21 January 2018

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16611371

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a pure antiestrogen on apoptosis and proliferation within human breast ductal carcinoma in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/16611371

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between c-erbB-2 and other tumor characteristics in breast cancer prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16611371

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of the EGF-receptor with cell kinetic and classical prognostic factors in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16611371

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proliferation of normal human breast tissue implanted into athymic nude mice is stimulated by estrogen but not progesterone

1 reference

https://pubmed.ncbi.nlm.nih.gov/16611371

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16611371

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/BCR1395

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19 January 2020

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19 January 2020

1 reference

Europe PubMed Central

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19 January 2020

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