Enantioselective metabolism of primaquine by human CYP2D6. (Q34994945)

5 August 2017

Enantioselective metabolism of primaquine by human CYP2D6. (English)

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5 August 2017

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Pius S Fasinu

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Ikhlas A Khan

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Ikhlas A Khan

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Bharathi Avula

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Babu L Tekwani

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N P Dhammika Nanayakkara

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H M T Bandara Herath

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Yan-Hong Wang

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Vijender R Adelli

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Mahmoud A Elsohly

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Shabana I Khan

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Brandon S Pybus

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Sean R Marcsisin

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Gregory A Reichard

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James D McChesney

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Larry A Walker

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17 December 2014

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507

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https://scigraph.springernature.com/pub.10.1186/1475-2875-13-507

5 August 2017

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cites work

Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers

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Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies

8 July 2018

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Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.

8 July 2018

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Methemoglobin generation by 8-aminoquinolines: effect of substitution at 5-position of primaquine

8 July 2018

1 reference

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An LC-MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model

8 July 2018

1 reference

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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301821

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

8 July 2018

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Understanding the mechanisms for metabolism-linked hemolytic toxicity of primaquine against glucose 6-phosphate dehydrogenase deficient human erythrocytes: evaluation of eryptotic pathway

8 July 2018

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Primaquine in vivax malaria: an update and review on management issues

8 July 2018

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Analysis of primaquine and its metabolite carboxyprimaquine in biological samples: enantiomeric separation, method validation and quantification

8 July 2018

1 reference

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Primaquine revisited six decades after its discovery

8 July 2018

1 reference

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Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development.

8 July 2018

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8-Aminoquinolines: future role as antiprotozoal drugs

8 July 2018

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Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I.

8 July 2018

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Primaquine-induced hemolytic anemia: role of splenic macrophages in the fate of 5-hydroxyprimaquine-treated rat erythrocytes

8 July 2018

1 reference

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Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine

8 July 2018

1 reference

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Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs.

8 July 2018

1 reference

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Primaquine sensitivity. Glucose-6-phosphate dehydrogenase deficiency: an inborn error of metabolism of medical and biological significance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301821

Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite

8 July 2018

1 reference

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8-(Omega-aminoalkylamino)quinolines as potential prophylactic antimalarials

8 July 2018

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Studies on the mechanisms of oxidation in the erythrocyte by metabolites of primaquine

8 July 2018

1 reference

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Antimalarials. 10. Synthesis of 4-substituted primaquine analogs as candidate antimalarials

8 July 2018

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Comparison of the Curative Antimalarial Activities and Toxicities of Primaquine and Its d and l Isomers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301821

Profiling primaquine metabolites in primary human hepatocytes using UHPLC-QTOF-MS with 13C stable isotope labeling.

8 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2875-13-507

Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2875-13-507

Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2875-13-507

Enantioselective analysis of primaquine and its metabolite carboxyprimaquine by capillary electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2875-13-507

Synthesis of [13C6]primaquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2875-13-507

Primaquine-induced hemolytic anemia: role of membrane lipid peroxidation and cytoskeletal protein alterations in the hemotoxicity of 5-hydroxyprimaquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2875-13-507

Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301821

Synthesis of certain hydroxy analogues of the antimalarial drug primaquine and their in vitro methemoglobin-producing and glutathione-depleting activity in human erythrocytes

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25518709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structure-activity relationships of putative primaquine metabolites causing methemoglobin formation in canine hemolysates

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25518709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hydroxylated metabolites of the antimalarial drug primaquine. Oxidation and redox cycling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25518709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1475-2875-13-507

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Dimensions Publication ID

5 August 2017

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5 August 2017

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