CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine (Q21034109)

2

Jason C

Sousa

1 reference

27 July 2022

Xiannu Jin

3

Xiannu

Jin

1 reference

27 July 2022

James A Ferguson

4

James A

Ferguson

1 reference

27 July 2022

Robert E Christian

5

Robert E

Christian

1 reference

27 July 2022

Rebecca Barnhart

6

Rebecca

Barnhart

1 reference

27 July 2022

Chau Vuong

7

Chau

Vuong

1 reference

27 July 2022

Richard J Sciotti

8

Richard J

Sciotti

1 reference

27 July 2022

Gregory A Reichard

9

Gregory A

Reichard

1 reference

27 July 2022

Michael P Kozar

10

Michael P

Kozar

1 reference

27 July 2022

Larry A Walker

11

Larry A

Walker

1 reference

27 July 2022

Colin Ohrt

12

Colin

Ohrt

1 reference

27 July 2022

Victor Melendez

13

Victor

Creative Commons Attribution 2.0 Generic

Melendez

1 reference

27 July 2022

language of work or name

English

0 references

publication date

2012

0 references

published in

Malaria Journal

0 references

volume

11

0 references

page(s)

259

0 references

issue

1

0 references

copyright license

start time

2 August 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

exact match

https://scigraph.springernature.com/pub.10.1186/1475-2875-11-259

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1475-2875-11-259

cites work

Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

Vivax malaria: neglected and not benign

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

Mapping the global extent of malaria in 2005.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

Pharmacokinetic interactions of antimalarial agents

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

The use of heterologously expressed drug metabolizing enzymes--state of the art and prospects for the future

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

Drug-induced hemolytic anemia.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

Antimalarial activity and inhibition of monoamine oxidases A and B by exo-erythrocytic antimalarials. Optical isomers of primaquine, N-acylated congeners, primaquine metabolites and 5-phenoxy-substituted analogues.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438098

High-performance liquid chromatographic analysis of the metabolism of primaquine and the identification of a new mammalian metabolite

29 November 2018

1 reference

12 December 2020

Structure-activity relationships of putative primaquine metabolites causing methemoglobin formation in canine hemolysates

1 reference

12 December 2020

Hydroxylated metabolites of the antimalarial drug primaquine. Oxidation and redox cycling

1 reference

12 December 2020

Side-chain hydroxylation in the metabolism of 8-aminoquinoline antiparasitic agents

1 reference

12 December 2020

Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine

1 reference

12 December 2020

Identifiers

DOI

10.1186/1475-2875-11-259

1 reference

Dimensions Publication ID

1590392

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1475-2875-11-259

1590392

1 reference

1 reference

1 reference