Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. (Q34988091)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21450905%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21 (English)

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27 January 2020

5

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27 January 2020

Jian Yu

6

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27 January 2020

1

Brian J Leibowitz

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27 January 2020

author name string

Wei Qiu

2

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27 January 2020

Hongtao Liu

3

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27 January 2020

Tao Cheng

4

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27 January 2020

publication date

30 March 2011

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Molecular Cancer Research

27 January 2020

published in

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27 January 2020

volume

9

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27 January 2020

issue

5

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27 January 2020

page(s)

616-625

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Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death

27 January 2020

cites work

1 reference

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Puma is required for p53-induced depletion of adult stem cells

8 July 2018

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Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.

8 July 2018

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Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

8 July 2018

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Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

8 July 2018

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Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

8 July 2018

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Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

8 July 2018

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Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.

8 July 2018

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Coexistence of quiescent and active adult stem cells in mammals

8 July 2018

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p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

8 July 2018

1 reference

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Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.

8 July 2018

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PUMA, a potent killer with or without p53

8 July 2018

1 reference

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8 July 2018

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Blinded by the Light: The Growing Complexity of p53

8 July 2018

1 reference

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Loss of p21Waf1/Cip1/Sdi1 enhances intestinal stem cell survival following radiation injury

8 July 2018

1 reference

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PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

8 July 2018

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The DNA damage response: ten years after

8 July 2018

1 reference

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p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability

8 July 2018

1 reference

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Identification of stem cells in small intestine and colon by marker gene Lgr5

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096742

p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096742

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

8 July 2018

1 reference

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Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

8 July 2018

1 reference

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The transcriptional targets of p53 in apoptosis control

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096742

ATM regulates target switching to escalating doses of radiation in the intestines

8 July 2018

1 reference

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Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine.

8 July 2018

1 reference

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096742

Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo

8 July 2018

1 reference

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

8 July 2018

1 reference

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PUMA mediates the apoptotic response to p53 in colorectal cancer cells

8 July 2018

1 reference

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The role of p53 in determining sensitivity to radiotherapy

8 July 2018

1 reference

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PUMA, a novel proapoptotic gene, is induced by p53

8 July 2018

1 reference

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PUMA induces the rapid apoptosis of colorectal cancer cells

8 July 2018

1 reference

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8 July 2018

Surfing the p53 network

1 reference

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Different impact of p53 and p21 on the radiation response of mouse tissues

8 July 2018

1 reference

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Stem cells: units of development, units of regeneration, and units in evolution

8 July 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

8 July 2018

1 reference

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Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

8 July 2018

1 reference

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The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice

8 July 2018

1 reference

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The influence of bone marrow depletion on intestinal radiation damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096742

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096742

A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096742

53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096742

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

26 October 2018

1 reference

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p53 is essential for chemotherapy-induced hair loss

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096742

26 October 2018

1 reference

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p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

26 October 2018

1 reference

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Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

9 December 2018

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12 December 2020

Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation

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12 December 2020

atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

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12 December 2020

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

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12 December 2020

Does cancer therapy trigger cell suicide?

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12 December 2020

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

12 December 2020

10.1158/1541-7786.MCR-11-0052

Identifiers

DOI

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27 January 2020

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27 January 2020

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