Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism (Q34954019)

5 August 2017

Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism (English)

1 reference

5 August 2017

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Fabrice Antigny

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Frédéric Becq

12

1 reference

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31 May 2020

author name string

C Norez

1

1 reference

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31 May 2020

C Vandebrouck

2

1 reference

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31 May 2020

J Bertrand

3

1 reference

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31 May 2020

E Durieu

5

1 reference

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31 May 2020

N Oumata

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

H Galons

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

A Chatelier

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

P Bois

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

L Meijer

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

language of work or name

English

0 references

publication date

1 November 2014

1 reference

British Journal of Pharmacology

5 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

171

1 reference

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31 May 2020

issue

21

1 reference

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31 May 2020

page(s)

4831-4849

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

The Concise Guide to PHARMACOLOGY 2013/14: enzymes.

31 May 2020

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The Concise Guide to PHARMACOLOGY 2013/14: ion channels

8 July 2018

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The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

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Managing the underlying cause of cystic fibrosis: a future role for potentiators and correctors

8 July 2018

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The β1-subunit of Na(v)1.5 cardiac sodium channel is required for a dominant negative effect through α-α interaction

8 July 2018

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Proteasomal inhibition restores biological function of mis-sense mutated dysferlin in patient-derived muscle cells

8 July 2018

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Transient receptor potential canonical channels are required for in vitro endothelial tube formation.

8 July 2018

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CFTR: folding, misfolding and correcting the ΔF508 conformational defect.

8 July 2018

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Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

8 July 2018

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Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation.

8 July 2018

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CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

8 July 2018

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Novel potent pharmacological cyclin-dependent kinase inhibitors

8 July 2018

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Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

8 July 2018

1 reference

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4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group

8 July 2018

1 reference

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Cyclin-dependent kinase inhibitors: a survey of recent patent literature

8 July 2018

1 reference

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Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date.

8 July 2018

1 reference

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Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

8 July 2018

1 reference

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Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation

8 July 2018

1 reference

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Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients

8 July 2018

1 reference

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State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy

8 July 2018

1 reference

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A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype

8 July 2018

1 reference

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Neutrophils in cystic fibrosis.

8 July 2018

1 reference

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CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

8 July 2018

1 reference

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CFTR function and prospects for therapy

8 July 2018

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Molecular and cellular aspects of protein misfolding and disease

8 July 2018

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Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

8 July 2018

1 reference

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Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants

8 July 2018

1 reference

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Measuring calcium signaling using genetically targetable fluorescent indicators

8 July 2018

1 reference

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A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days

8 July 2018

1 reference

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Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

8 July 2018

1 reference

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Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

8 July 2018

1 reference

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Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.

8 July 2018

1 reference

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Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat

8 July 2018

1 reference

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Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules

8 July 2018

1 reference

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Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome

8 July 2018

1 reference

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Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers

8 July 2018

1 reference

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Antihypertensive 1,4-dihydropyridines as correctors of the cystic fibrosis transmembrane conductance regulator channel gating defect caused by cystic fibrosis mutations.

8 July 2018

1 reference

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ERAD: the long road to destruction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Roscovitine targets, protein kinases and pyridoxal kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Brugada syndrome and fever: genetic and molecular characterization of patients carrying SCN5A mutations.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

The relationship between cell proliferation, Cl- secretion, and renal cyst growth: a study using CFTR inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Pharmacological chaperone action on G-protein-coupled receptors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials

8 July 2018

1 reference

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Quality control in the endoplasmic reticulum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Pharmacological inhibitors of cyclin-dependent kinases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Isolation of CF cell lines corrected at DeltaF508-CFTR locus by SFHR-mediated targeting

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

S-nitrosoglutathione increases cystic fibrosis transmembrane regulator maturation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Rescue of dysfunctional deltaF508-CFTR chloride channel activity by IBMX.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Effect of host modification and age on airway epithelial gene transfer mediated by a murine leukemia virus-derived vector

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Prostaglandin F2alpha stimulates CFTR activity by PKA- and PKC-dependent phosphorylation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Inhibition of the cystic fibrosis transmembrane conductance regulator by ATP-sensitive K+ channel regulators

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Degradation of CFTR by the ubiquitin-proteasome pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Panning transfected cells for electrophysiological studies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Expression of normal and cystic fibrosis phenotypes by continuous airway epithelial cell lines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Seliciclib in malignancies

8 July 2018

1 reference

Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.

21 January 2018

1 reference

Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells

21 January 2018

1 reference

Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells

21 January 2018

1 reference

Pharmacodynamic effects of seliciclib, an orally administered cell cycle modulator, in undifferentiated nasopharyngeal cancer

21 January 2018

1 reference

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.

21 January 2018

1 reference

Airway delivery of low-dose miglustat normalizes nasal potential difference in F508del cystic fibrosis mice

21 January 2018

1 reference

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

1 reference

In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance

21 January 2018

1 reference

Purification of CK1 by affinity chromatography on immobilised axin.

21 January 2018

1 reference

Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives

21 January 2018

1 reference

Inhibition of cyclin-dependent kinases by purine analogues.

21 January 2018

1 reference

Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications.

21 January 2018

1 reference

Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294108

Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR

26 October 2018

1 reference

12 December 2020

Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome

1 reference

12 December 2020

A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function

1 reference

12 December 2020

Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis

1 reference

12 December 2020

Identifiers

DOI

10.1111/BPH.12859

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25065395%20AND%20SRC:MED&resulttype=core&format=json