Perspectives on NMR in drug discovery: a technique comes of age (Q34930997)

5 August 2017

1 reference

title

Perspectives on NMR in drug discovery: a technique comes of age (English)

1 reference

5 August 2017

1 reference

Hartmut Oschkinat

12

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David Cowburn

David Cowburn

3

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Harald Schwalbe

Harald Schwalbe

14

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Ernest Giralt i Lledó

Ernest Giralt

5

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Claudio Luchinat

Claudio Luchinat

10

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Ivano Bertini

2

Ivano Bertini

1 reference

5 August 2017

Maurizio Pellecchia

1

1 reference

5 August 2017

Claudio Dalvit

4

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5 August 2017

Wolfgang Jahnke

6

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5 August 2017

Thomas L James

7

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5 August 2017

Steve W Homans

8

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5 August 2017

Horst Kessler

9

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5 August 2017

Bernd Meyer

11

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5 August 2017

Jeff Peng

13

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5 August 2017

Gregg Siegal

15

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5 August 2017

1 September 2008

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Nature Reviews Drug Discovery

5 August 2017

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5 August 2017

7

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5 August 2017

9

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5 August 2017

738-745

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https://scigraph.springernature.com/pub.10.1038/nrd2606

5 August 2017

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Combining in silico tools and NMR data to validate protein-ligand structural models: application to matrix metalloproteinases

8 July 2018

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8 July 2018

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Investigation of ligand-receptor systems by high-resolution solid-state NMR: recent progress and perspectives

8 July 2018

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Fragonomics: fragment-based drug discovery

8 July 2018

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NMR fragment screening: tackling protein-protein interaction targets

8 July 2018

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Maximizing discovery efficiency with a computationally driven fragment approach

8 July 2018

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Conformational variability of matrix metalloproteinases: beyond a single 3D structure

8 July 2018

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Druggability indices for protein targets derived from NMR-based screening data

8 July 2018

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8 July 2018

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TINS, target immobilized NMR screening: an efficient and sensitive method for ligand discovery

8 July 2018

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The discovery of novel protein kinase inhibitors by using fragment-based high-throughput x-ray crystallography

8 July 2018

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NMR-based techniques in the hit identification and optimisation processes

8 July 2018

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8 July 2018

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Making drugs on proteins: site-directed ligand discovery for fragment-based lead assembly

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Ligand efficiency: a useful metric for lead selection

8 July 2018

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8 July 2018

1 reference

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8 July 2018

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8 July 2018

1 reference

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8 July 2018

1 reference

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A ‘Rule of Three’ for fragment-based lead discovery?

8 July 2018

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8 July 2018

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8 July 2018

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Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy

8 July 2018

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8 July 2018

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Applications of SHAPES screening in drug discovery.

8 July 2018

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8 July 2018

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8 July 2018

1 reference

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8 July 2018

NMR in drug discovery

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8 July 2018

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8 July 2018

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Spin label enhanced NMR screening

8 July 2018

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8 July 2018

1 reference

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8 July 2018

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8 July 2018

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NMR-based screening in drug discovery

8 July 2018

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8 July 2018

1 reference

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Privileged molecules for protein binding identified from NMR-based screening

8 July 2018

1 reference

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Diversity screening versus focussed screening in drug discovery

8 July 2018

1 reference

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The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.

8 July 2018

1 reference

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The maximal affinity of ligands

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

1 reference

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8 July 2018

1 reference

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26 October 2018

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26 October 2018

1 reference

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Identification by 19F NMR of traditional Chinese medicinal plants possessing prolyl oligopeptidase inhibitory activity

26 October 2018

1 reference

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26 October 2018

1 reference

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NMR characterization of kinase p38 dynamics in free and ligand-bound forms

26 October 2018

1 reference

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Ligand efficiency indices as guideposts for drug discovery.

26 October 2018

1 reference

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Fragment-based lead discovery using X-ray crystallography.

26 October 2018

1 reference

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26 October 2018

1 reference

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NMR backbone assignment of a protein kinase catalytic domain by a combination of several approaches: application to the catalytic subunit of cAMP-dependent protein kinase.

26 October 2018

1 reference

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Fragment-Based Drug Discovery

26 October 2018

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NMR-based characterization of phenothiazines as a RNA binding scaffold

26 October 2018

1 reference

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SOS-NMR: a saturation transfer NMR-based method for determining the structures of protein-ligand complexes

26 October 2018

1 reference

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A tetraguanidinium ligand binds to the surface of the tetramerization domain of protein P53.

26 October 2018

1 reference

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The effect of relaxation on the epitope mapping by saturation transfer difference NMR.

26 October 2018

1 reference

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26 October 2018

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Chris Lipinski discusses life and chemistry after the Rule of Five.

26 October 2018

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An approach for high-throughput structure determination of proteins by NMR spectroscopy.

26 October 2018

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The INPHARMA Method: Protein-Mediated Interligand NOEs for Pharmacophore Mapping

26 October 2018

1 reference

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Combined solid state and solution NMR studies of α,ɛ-15N labeled bovine rhodopsin

26 October 2018

1 reference

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In-Cell NMR Spectroscopy

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NMR-based structural characterization of large protein-ligand interactions

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A general NMR method for rapid, efficient, and reliable biochemical screening

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1 reference

Spatial localization of ligand binding sites from electron current density surfaces calculated from NMR chemical shift perturbations

31 March 2020

1 reference

Characterization of Protein−Ligand Interactions by High-Resolution Solid-State NMR Spectroscopy

31 March 2020

1 reference

Perspectives of biomolecular NMR in drug discovery: the blessing and curse of versatility

31 March 2020

1 reference

NMR-based screening: a powerful tool in fragment-based drug discovery

31 March 2020

1 reference

A fast and robust 19F NMR-based method for finding new HIV-1 protease inhibitors

31 March 2020

1 reference

Traditional Chinese medicines with caspase-inhibitory activity

31 March 2020

1 reference

Fluorine-NMR competition binding experiments for high-throughput screening of large compound mixtures

31 March 2020

1 reference

SAR by ILOEs: an NMR-based approach to reverse chemical genetics

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19172689

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19172689

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD2606

1 reference

5 August 2017

1 reference

5 August 2017

1 reference