NMR-based techniques in the hit identification and optimisation processes (Q35976375)

11 August 2017

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title

NMR-based techniques in the hit identification and optimisation processes (English)

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11 August 2017

Barbara Becattini

2

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Martino Forino

object named as

Martino Forino

5

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Roberto Fattorusso

object named as

Roberto Fattorusso

4

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Marco Fragai

object named as

Marco Fragai

6

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author name string

Maurizio Pellecchia

1

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11 August 2017

Kevin J Crowell

3

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11 August 2017

Dawoon Jung

7

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11 August 2017

Tomas Mustelin

8

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11 August 2017

Lutz Tautz

9

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11 August 2017

language of work or name

English

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publication date

1 December 2004

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Expert Opinion on Therapeutic Targets

11 August 2017

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11 August 2017

8

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11 August 2017

6

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11 August 2017

597-611

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11 August 2017

NMR in drug discovery

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Application of NMR screening in drug discovery

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NMR-based screening method for transglutaminases: rapid analysis of their substrate specificities and reaction rates

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NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors

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NMR methods for the determination of protein-ligand dissociation constants

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Fluorine nuclear magnetic resonance of fluorinated ligands

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Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague.

21 January 2018

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Glucose transporter of Escherichia coli: NMR characterization of the phosphocysteine form of the IIB(Glc) domain and its binding interface with the IIA(Glc) subunit.

21 January 2018

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The catalytic mechanism of Cdc25A phosphatase

21 January 2018

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Use of selective Trp side chain labeling to characterize protein-protein and protein-ligand interactions by NMR spectroscopy

21 January 2018

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Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water.

21 January 2018

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High-throughput NMR-based screening with competition binding experiments.

21 January 2018

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Caspases: preparation and characterization

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The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

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Reliable high-throughput functional screening with 3-FABS.

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A Strategy for High-Throughput Assay Development Using Leads Derived from Nuclear Magnetic Resonance-Based Screening

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The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.

21 January 2018

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Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

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Second-site NMR screening and linker design

21 January 2018

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Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules.

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Property distribution of drug-related chemical databases.

21 January 2018

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The properties of known drugs. 1. Molecular frameworks

21 January 2018

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Development and validation of a genetic algorithm for flexible docking

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A geometric approach to macromolecule-ligand interactions

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A fast flexible docking method using an incremental construction algorithm.

21 January 2018

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LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites

21 January 2018

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Consensus scoring for ligand/protein interactions

21 January 2018

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Evaluation of the FLEXX incremental construction algorithm for protein-ligand docking

21 January 2018

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Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

21 January 2018

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NMR-based screening in drug discovery

21 January 2018

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Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.

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IAP family proteins--suppressors of apoptosis

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

21 January 2018

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Fragment-based lead discovery

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WaterLOGSY as a method for primary NMR screening: practical aspects and range of applicability.

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21 January 2018

Identifiers

DOI

10.1517/14728222.8.6.597

1 reference

11 August 2017

1 reference