Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth (Q34838111)

4 August 2017

Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth (English)

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4 August 2017

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Lingyi Fu

1

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4 August 2017

Wangbing Chen

2

1 reference

4 August 2017

Wei Guo

3

1 reference

4 August 2017

Jingshu Wang

4

1 reference

4 August 2017

Yun Tian

5

1 reference

4 August 2017

Dingbo Shi

6

1 reference

4 August 2017

Xiaohong Zhang

7

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4 August 2017

Huijuan Qiu

8

1 reference

4 August 2017

Xiangsheng Xiao

9

1 reference

4 August 2017

Tiebang Kang

10

1 reference

4 August 2017

Wenlin Huang

11

1 reference

4 August 2017

Shusen Wang

12

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4 August 2017

Wuguo Deng

13

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4 August 2017

language of work or name

English

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publication date

15 July 2013

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4 August 2017

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4 August 2017

8

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4 August 2017

e69240

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4 August 2017

7

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Creative Commons Attribution 4.0 International

4 August 2017

start time

15 July 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity

8 July 2018

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Nicotine promotes proliferation of human nasopharyngeal carcinoma cells by regulating α7AChR, ERK, HIF-1α and VEGF/PEDF signaling

8 July 2018

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Radiosensitization effects of berberine on human breast cancer cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

Berberine increases the expression of NHE3 and AQP4 in sennosideA-induced diarrhoea model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway.

8 July 2018

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8 July 2018

Cancer statistics, 2012

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Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

Berberine inhibits pulmonary metastasis through down-regulation of MMP in metastatic B16F-10 melanoma cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

Berberine suppresses androgen receptor signaling in prostate cancer.

8 July 2018

1 reference

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Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria

8 July 2018

1 reference

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Milestones in the use of chemotherapy for the management of non-small cell lung cancer (NSCLC).

8 July 2018

1 reference

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Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway.

8 July 2018

1 reference

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hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis

8 July 2018

1 reference

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Oral Chinese herbal medicine (CHM) as an adjuvant treatment during chemotherapy for non-small cell lung cancer: A systematic review

8 July 2018

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

8 July 2018

1 reference

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A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways

8 July 2018

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Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers

8 July 2018

1 reference

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HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

8 July 2018

1 reference

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Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death

8 July 2018

1 reference

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Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cells

8 July 2018

1 reference

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Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

Molecular mechanisms of caspase regulation during apoptosis

8 July 2018

1 reference

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Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

The biology of VEGF and its receptors

8 July 2018

1 reference

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Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

8 July 2018

1 reference

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Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer

8 July 2018

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Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

8 July 2018

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The AP2/EREBP family of plant transcription factors

8 July 2018

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A review on the chemical and pharmacological aspects of genus Berberis

8 July 2018

1 reference

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Evaluating the traditional Chinese literature for herbal formulae and individual herbs used for age-related dementia and memory impairment.

8 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0069240

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0069240

Upregulating reverse cholesterol transport with cholesteryl ester transfer protein inhibition requires combination with the LDL-lowering drug berberine in dyslipidemic hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0069240

Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin β1 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0069240

Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0069240

p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0069240

Prognostic value of hTERT mRNA expression in surgical samples of lung cancer patients: the European Early Lung Cancer Project.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

[Effect of berberine on left ventricular remodeling in renovascular hypertensive rats].

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

Cyclooxygenase 2 and carcinogenesis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711861

HER2 and COX2 expression in human prostate cancer

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23869238

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23869238

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antidiarrheal activity, chemical and toxicity profile of Berberis aristata

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23869238

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0069240

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference