Designed transcription factors as tools for therapeutics and functional genomics (Q34816185)

4 August 2017

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title

Designed transcription factors as tools for therapeutics and functional genomics (English)

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4 August 2017

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2

Edward J Rebar

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4 August 2017

1

Fyodor D Urnov

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PubMed ID

12213587

4 August 2017

language of work or name

English

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publication date

1 September 2002

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4 August 2017

Biochemical Pharmacology

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4 August 2017

64

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4 August 2017

919-923

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4 August 2017

5-6

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MIPS: a database for genomes and protein sequences

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Identifying regulatory networks by combinatorial analysis of promoter elements

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Functional organization of the yeast proteome by systematic analysis of protein complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

When the SWI/SNF complex remodels...the cell cycle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Transcription therapy for cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Biotechnologies and therapeutics: chromatin as a target.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo. Fourth in review series on chromatin dynamics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

DNA methylation in health and disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points

7 January 2021

1 reference

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Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides

7 January 2021

1 reference

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RNAi: nature abhors a double-strand

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Synthesis, analysis, purification, and intracellular delivery of peptide nucleic acids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Sequence-specific targeting of duplex DNA by peptide nucleic acids via triplex strand invasion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Molecular recognition of DNA by small molecules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Design and selection of novel Cys2His2 zinc finger proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Concerted evolution of structure and function in a miniature protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Engineering polydactyl zinc-finger transcription factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Identification of potential target genes for Adr1p through characterization of essential nucleotides in UAS1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

DNA binding through distinct domains of zinc-finger-homeodomain protein AREB6 has different effects on gene transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

The delta-crystallin enhancer-binding protein delta EF1 is a repressor of E2-box-mediated gene activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Target Detection Assay (TDA): a versatile procedure to determine DNA binding sites as demonstrated on SP1 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

DNA-binding specificity of NGFI-A and related zinc finger transcription factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: determinants of affinity and sequence specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Positive and negative regulation of endogenous genes by designed transcription factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

A novel four zinc-finger protein targeted against p190(BcrAbl) fusion oncogene cDNA: utilisation of zinc-finger recognition codes

7 January 2021

1 reference

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The artificial zinc finger coding gene 'Jazz' binds the utrophin promoter and activates transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Toward rules relating zinc finger protein sequences and DNA binding site preferences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Length-encoded multiplex binding site determination: application to zinc finger proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Mutations in the zinc fingers of ADR1 that change the specificity of DNA binding and transactivation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Zinc finger phage: affinity selection of fingers with new DNA-binding specificities

7 January 2021

1 reference

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Phage display methods for selecting zinc finger proteins with novel DNA-binding specificities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

In vitro selection of zinc fingers with altered DNA-binding specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

A zinc finger directory for high-affinity DNA recognition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

7 January 2021

1 reference

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Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Design of polydactyl zinc-finger proteins for unique addressing within complex genomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Zinc finger proteins as designer transcription factors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Design of polyzinc finger peptides with structured linkers

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Structure-based design of a dimeric zinc finger protein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Dimerization of zinc fingers mediated by peptides evolved in vitro from random sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

DNA recognition by Cys2His2 zinc finger proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Transcription factor loading on the MMTV promoter: a bimodal mechanism for promoter activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Transcriptional regulation of mammalian genes in vivo. A tale of two templates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Genome-wide location and function of DNA binding proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

A feel for the template: zinc finger protein transcription factors and chromatin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis

7 January 2021

1 reference

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7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Transcription and chromatin converge: lessons from yeast genetics.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Http://C. elegans: mining the functional genomic landscape

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Deciphering gene expression regulatory networks.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

Regulation of the MDR1 gene by transcriptional repressors selected using peptide combinatorial libraries

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901150-4

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(02)01150-4

1 reference

4 August 2017

1 reference

PubMed ID

12213587