Biotechnologies and therapeutics: chromatin as a target. (Q34563296)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11893498%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

title

Biotechnologies and therapeutics: chromatin as a target (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11893498%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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Andreas Reik

1

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8 December 2019

publication date

1 April 2002

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Current Opinion in Genetics & Development

8 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11893498%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

volume

12

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8 December 2019

issue

2

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8 December 2019

page(s)

233-242

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11893498%20AND%20SRC:MED&resulttype=core&format=json

publication type of scholarly work

8 December 2019

review article

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Transcription therapy for cancer

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Untangling the ErbB signalling network

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Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

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7 January 2021

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7 January 2021

DNA methylation, methyltransferases, and cancer

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7 January 2021

Methyl CpG binding proteins: coupling chromatin architecture to gene regulation

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7 January 2021

Methylation-induced repression--belts, braces, and chromatin

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7 January 2021

Histone deacetylase as a therapeutic target

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7 January 2021

DNA methylation in health and disease

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7 January 2021

Inhibitors of histone deacetylase as new anticancer agents

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7 January 2021

Histone deacetylase inhibitors as new cancer drugs

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7 January 2021

Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues

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7 January 2021

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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7 January 2021

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

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7 January 2021

Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter

1 reference

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7 January 2021

Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching.

1 reference

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7 January 2021

An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells

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7 January 2021

Unanticipated repression function linked to erythroid Krüppel-like factor

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7 January 2021

Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin

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7 January 2021

The language of covalent histone modifications

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7 January 2021

CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Regulation of activity of the transcription factor GATA-1 by acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Phosphorylation of GATA-1 increases its DNA-binding affinity and is correlated with induction of human K562 erythroleukaemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Mechanism for fetal globin gene expression: role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Loss of PU.1 Expression Following Inhibition of Histone Deacetylases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

The beta-globin locus control region versus gene therapy vectors: a struggle for expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

1 reference

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7 January 2021

CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

A chromatin insulator protects retrovirus vectors from chromosomal position effects

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Position-independent human beta-globin gene expression mediated by a recombinant adeno-associated virus vector carrying the chicken beta-globin insulator

1 reference

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7 January 2021

Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

DNA recognition by Cys2His2 zinc finger proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Expressing the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Regulation of the MDR1 gene by transcriptional repressors selected using peptide combinatorial libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Design and selection of novel Cys2His2 zinc finger proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Positive and negative regulation of endogenous genes by designed transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Nuclear cloning and epigenetic reprogramming of the genome

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Prospects for the use of nuclear transfer in human transplantation

1 reference

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7 January 2021

Production of cloned pigs from in vitro systems

1 reference

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7 January 2021

Human Factor IX Transgenic Sheep Produced by Transfer of Nuclei from Transfected Fetal Fibroblasts

1 reference

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7 January 2021

Genetic rescue of an endangered mammal by cross-species nuclear transfer using post-mortem somatic cells.

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7 January 2021

Imprinting and the epigenetic asymmetry between parental genomes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith–Wiedemann and Simpson–Golabi–Behmel syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Epigenetic instability in ES cells and cloned mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Generation of mice from wild-type and targeted ES cells by nuclear cloning

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Factors affecting the developmental potential of cloned mammalian embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Typical demethylation events in cloned pig embryos. Clues on species-specific differences in epigenetic reprogramming of a cloned donor genome

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Aberrant methylation of donor genome in cloned bovine embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Molecular mechanisms of male germ cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Epigenetic reprogramming in mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Active demethylation of the paternal genome in the mouse zygote

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Developmental biology. Don't clone humans!

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7 January 2021

The plasticity of dendritic cell responses to pathogens and their components

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Identifying regulatory networks by combinatorial analysis of promoter elements

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Identification of in vivo DNA targets of chromatin proteins using tethered dam methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Chromatin profiling using targeted DNA adenine methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Identification of a small molecule inhibitor of Sir2p

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Dynamic reprogramming of DNA methylation in the early mouse embryo.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

Genome-wide methylation patterns in normal and uniparental early mouse embryos

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900291-5

7 January 2021

10.1016/S0959-437X(02)00291-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11893498%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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