Targeting Rho-GTPases in immune cell migration and inflammation (Q34803380)

4 August 2017

1 reference

8 February 2021

Targeting Rho-GTPases in immune cell migration and inflammation (English)

1 reference

Rho-associated protein kinase 1/2

4 August 2017

1 reference

4 August 2019

1 reference

protein kinase inhibitors

28 September 2019

1 reference

2 October 2019

1 reference

12 October 2019

1 reference

20 November 2019

1 reference

28 November 2019

1 reference

10 August 2020

1 reference

8 February 2021

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571448%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Wolfgang Weninger

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571448%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Marcia A Munoz

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571448%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

2 July 2014

1 reference

24571448

British Journal of Pharmacology

4 August 2017

1 December 2014

13 references

3 April 2019

4 August 2019

20 August 2019

28 September 2019

2 October 2019

12 October 2019

18 October 2019

16 November 2019

20 November 2019

28 November 2019

11 December 2019

10 August 2020

8 February 2021

14 references

3 April 2019

4 August 2019

20 August 2019

28 September 2019

2 October 2019

12 October 2019

18 October 2019

16 November 2019

20 November 2019

28 November 2019

11 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571448%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

10 August 2020

8 February 2021

171

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571448%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571448%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

5491-5506

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571448%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 4.0 International

7 June 2020

copyright license

13 references

3 April 2019

4 August 2019

20 August 2019

28 September 2019

2 October 2019

12 October 2019

18 October 2019

16 November 2019

20 November 2019

28 November 2019

11 December 2019

10 August 2020

on focus list of Wikimedia project

8 February 2021

ScienceSource

0 references

cites work

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8 July 2018

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FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas

8 July 2018

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Targeting cells in motion: migrating toward improved therapies

8 July 2018

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Targeting the shift from M1 to M2 macrophages in experimental autoimmune encephalomyelitis mice treated with fasudil

8 July 2018

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Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

8 July 2018

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Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors

8 July 2018

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Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility

8 July 2018

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8 July 2018

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Hanging in the balance: endogenous anti-inflammatory mechanisms in tissue repair and fibrosis

8 July 2018

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Actin cortex mechanics and cellular morphogenesis

8 July 2018

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Is there a future for prenyltransferase inhibitors in cancer therapy?

8 July 2018

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Cell mechanics control rapid transitions between blebs and lamellipodia during migration

8 July 2018

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

8 July 2018

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ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion

8 July 2018

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Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42.

8 July 2018

1 reference

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Adoptive immunotherapy for cancer: harnessing the T cell response

8 July 2018

1 reference

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Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease

8 July 2018

1 reference

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Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

8 July 2018

1 reference

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8 July 2018

PAKs in human disease

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Inhibition and termination of physiological responses by GTPase activating proteins

8 July 2018

1 reference

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RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response

8 July 2018

1 reference

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Cancer immunotherapy comes of age

8 July 2018

1 reference

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Inhibition of Rho kinases increases directional motility of microvascular endothelial cells

8 July 2018

1 reference

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Vasospasm after aneurysmal subarachnoid hemorrhage: review of randomized controlled trials and meta-analyses in the literature

8 July 2018

1 reference

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High-throughput flow cytometry bead-based multiplex assay for identification of Rho GTPase inhibitors

8 July 2018

1 reference

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LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells

8 July 2018

1 reference

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Anthrax lethal toxin-mediated disruption of endothelial VE-cadherin is attenuated by inhibition of the Rho-associated kinase pathway

8 July 2018

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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

8 July 2018

1 reference

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Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension

8 July 2018

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The biochemistry of asthma

8 July 2018

1 reference

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Cdc42 in oncogenic transformation, invasion, and tumorigenesis

8 July 2018

1 reference

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Rho GTPases as regulators of morphological neuroplasticity

8 July 2018

1 reference

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Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma

8 July 2018

1 reference

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7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration

8 July 2018

1 reference

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Novel inhibitors of Rac1 in metastatic breast cancer.

8 July 2018

1 reference

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Dynamics of the Rho-family small GTPases in actin regulation and motility

8 July 2018

1 reference

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Immunologic aspects and rejection in solid organ versus reconstructive transplantation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Mechanisms of leukocyte transendothelial migration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Mechanisms of force generation and force transmission during interstitial leukocyte migration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Tetrahydroisoquinoline Derivatives As Highly Selective and Potent Rho Kinase Inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Spatio-temporal Rho GTPase signaling - where are we now?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Regulation of actin cytoskeleton dynamics in cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

WASP: a key immunological multitasker

8 July 2018

1 reference

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Actin, a central player in cell shape and movement

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Non-muscle myosin II takes centre stage in cell adhesion and migration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Rho kinase (ROCK) inhibitors and their application to inflammatory disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Virtual screening approach for the identification of new Rac1 inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Mechanical modes of 'amoeboid' cell migration.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Actin nucleation and elongation factors: mechanisms and interplay

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

CD44 mediates successful interstitial navigation by killer T cells and enables efficient antitumor immunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Moving targets: cell migration inhibitors as new anti-inflammatory therapies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Interstitial leukocyte migration and immune function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

The development of allergic inflammation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Blebs lead the way: how to migrate without lamellipodia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Cell motility through plasma membrane blebbing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Mechanism of shape determination in motile cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Rho GTPases in cancer cell biology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Rapid leukocyte migration by integrin-independent flowing and squeezing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Molecular mechanisms of autoimmunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Applications for ROCK kinase inhibition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Getting to the site of inflammation: the leukocyte adhesion cascade updated

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Random migration precedes stable target cell interactions of tumor-infiltrating T cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Reassembly of contractile actin cortex in cell blebs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Tuba stimulates intracellular N-WASP-dependent actin assembly

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Rational design and applications of a Rac GTPase-specific small molecule inhibitor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Paradoxical roles of the immune system during cancer development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Lipid posttranslational modifications. Farnesyl transferase inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Design of effective immunotherapy for human autoimmunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Cdc42: new roads to travel

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Rho and Rac take center stage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Cell migration: Rho GTPases lead the way

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Rho GTPases as therapeutic targets for the treatment of inflammatory diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Cellular motility driven by assembly and disassembly of actin filaments

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Immune-mediated inflammatory disorders (I.M.I.D.s): the economic and clinical costs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Rho GTPases in cell biology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils.

8 July 2018

1 reference

Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor

21 January 2018

1 reference

Targeting leukotriene B4 in inflammation

21 January 2018

1 reference

Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice.

21 January 2018

1 reference

Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension

21 January 2018

1 reference

Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis

21 January 2018

1 reference

A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic mice

21 January 2018

1 reference

Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension

21 January 2018

1 reference

Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

21 January 2018

1 reference

Partial protective effect of Y-27632, a Rho kinase inhibitor, against hepatic ischemia-reperfusion injury in rats

21 January 2018

1 reference

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina

21 January 2018

1 reference

WF-536 inhibits metastatic invasion by enhancing the host cell barrier and inhibiting tumour cell motility

21 January 2018

1 reference

Enhancement of endothelial progenitor cell numbers and migration by H1152, a Rho kinase specific inhibitor.

21 January 2018

1 reference

Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.

21 January 2018

1 reference

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation

21 January 2018

1 reference

Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrin alpha2beta1.

21 January 2018

1 reference

Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction

21 January 2018

1 reference

The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation

21 January 2018

1 reference

Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy

21 January 2018

1 reference

Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study

21 January 2018

1 reference

Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension

21 January 2018

1 reference

Attenuation of endotoxin-induced acute lung injury by the Rho-associated kinase inhibitor, Y-27632.

21 January 2018

1 reference

How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin

21 January 2018

1 reference

Dissection of amoeboid movement into two mechanically distinct modes.

21 January 2018

1 reference

Effects of fasudil in patients with high-altitude pulmonary hypertension

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282076

Acute serum amyloid A regulates cytoskeletal rearrangement, cell matrix interactions and promotes cell migration in rheumatoid arthritis

26 October 2018

1 reference

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading

21 January 2018

1 reference

12 December 2020

The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury

1 reference

12 December 2020

Therapeutic effect of Y-27632 on chronic allograft nephropathy in rats

1 reference

12 December 2020

Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys

1 reference

12 December 2020

Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y-27632

1 reference

12 December 2020

Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity

1 reference

12 December 2020

Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities

1 reference

12 December 2020

Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers

1 reference

12 December 2020

The effects of HA compound calcium antagonists on delayed cerebral vasospasm in dogs

1 reference

12 December 2020

Identifiers

DOI

10.1111/BPH.12658

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571448%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571448%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

24571448

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571448%20AND%20SRC:MED&resulttype=core&format=json