5,6-dimethylxanthenone-4-acetic acid (DMXAA): a new biological response modifier for cancer therapy (Q34802885)

4 August 2017

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title

5,6-dimethylxanthenone-4-acetic acid (DMXAA): a new biological response modifier for cancer therapy (English)

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4 August 2017

Shufeng Zhou

1

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4 August 2017

Philip Kestell

series ordinal

2

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4 August 2017

Bruce C Baguley

series ordinal

3

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4 August 2017

James W Paxton

series ordinal

4

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4 August 2017

publication date

1 August 2002

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Investigational New Drugs

4 August 2017

published in

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4 August 2017

volume

20

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4 August 2017

issue

3

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4 August 2017

page(s)

281-295

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https://scigraph.springernature.com/pub.10.1023/a:1016215015530

4 August 2017

exact match

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Suppression of serum tumour necrosis factor-alpha by thalidomide does not lead to reversal of tumour vascular collapse and anti-tumour activity of 5,6-dimethylxanthenone-4-acetic acid

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Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci.

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Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid: concomitant reduction of serum tumour necrosis factor-alpha and enhancement of anti-tumour activity

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Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages. Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation.

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12 December 2020

Induction of tumor necrosis factor-alpha messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488).

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Effects of the serotonin receptor antagonist cyproheptadine on the activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

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Thalidomide increases both intra-tumoural tumour necrosis factor-alpha production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid

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12 December 2020

Cytokine induction and therapeutic synergy with interleukin-2 against murine renal and colon cancers by xanthenone-4-acetic acid derivatives

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12 December 2020

Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid

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12 December 2020

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12 December 2020

Species differences in the metabolism of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in vitro: implications for prediction of metabolic interactions in vivo

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12 December 2020

Induction of tumour necrosis factor-alpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid

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12 December 2020

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12 December 2020

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12 December 2020

Determination of the covalent adducts of the novel anti-cancer agent 5,6-dimethylxanthenone-4-acetic acid in biological samples by high-performance liquid chromatography

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Anti-tumour activity of flavone acetic acid (NSC 347512) in mice--influence of immune status

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12 December 2020

Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice by thalidomide

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12 December 2020

Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide.

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12 December 2020

Serotonin involvement in the antitumour and host effects of flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid

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12 December 2020

Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice

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12 December 2020

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12 December 2020

Preclinical prediction of factors influencing the elimination of 5,6-dimethylxanthenone-4-acetic acid, a new anticancer drug

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12 December 2020

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12 December 2020

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12 December 2020

Determination of two major metabolites of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid in hepatic microsomal incubations by high-performance liquid chromatography with fluorescence detection

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Induction of STAT and NFkappaB activation by the antitumor agents 5,6-dimethylxanthenone-4-acetic acid and flavone acetic acid in a murine macrophage cell line

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12 December 2020

Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs

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12 December 2020

Identification of the human liver cytochrome P450 isoenzyme responsible for the 6-methylhydroxylation of the novel anticancer drug 5,6-dimethylxanthenone-4-acetic acid

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12 December 2020

Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice

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12 December 2020

Synthesis of the CC-chemokines MIP-1alpha, MIP-1beta, and RANTES is associated with a type 1 immune response.

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12 December 2020

Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation

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12 December 2020

Stimulation of tumors to synthesize tumor necrosis factor-alpha in situ using 5,6-dimethylxanthenone-4-acetic acid: a novel approach to cancer therapy

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12 December 2020

Serotonin antagonists

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12 December 2020

The structure and function of the UDP-glucuronosyltransferase gene family

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12 December 2020

Identifiers

DOI

10.1023/A:1016215015530

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Dimensions Publication ID

4 August 2017

1045426122

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