The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway. (Q34746718)

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English	The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway.	scientific article

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25 February 2020

The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway (English)

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25 February 2020

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25 February 2020

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Tao Jia

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25 February 2020

Li Zhang

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25 February 2020

Min Zhang

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25 February 2020

Gang Wang

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25 February 2020

Jun Zhang

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25 February 2020

Zheng Zhao

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25 February 2020

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30 November 2014

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25 February 2020

Cancer Cell International

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25 February 2020

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25 February 2020

1

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25 February 2020

126

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25 February 2020

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Creative Commons Attribution 4.0 International

30 November 2014

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Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression

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Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species

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Distinct biological roles for the akt family in mammary tumor progression

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7 July 2018

Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2

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7 July 2018

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization

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7 July 2018

Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells.

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7 July 2018

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

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7 July 2018

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

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7 July 2018

EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein

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7 July 2018

Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent

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7 July 2018

Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer

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7 July 2018

Knockdown of S-phase kinase-associated protein-2 expression in MCF-7 inhibits cell growth and enhances the cytotoxic effects of epirubicin

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7 July 2018

Curcumin as "Curecumin": from kitchen to clinic.

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Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines

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The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells

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Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms.

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Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

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Curcumin exerts multiple suppressive effects on human breast carcinoma cells

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12 December 2020

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