The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice (Q34726907)

4 August 2017

The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice (English)

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4 August 2017

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Lindsey B Gano

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4 August 2017

Anthony J Donato

2

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4 August 2017

Hamza M Pasha

3

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4 August 2017

Christopher M Hearon

4

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4 August 2017

Amy L Sindler

5

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4 August 2017

Douglas R Seals

6

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4 August 2017

17 October 2014

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American Journal of Physiology Heart and Circulatory Physiology

4 August 2017

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4 August 2017

307

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4 August 2017

H1754-63

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4 August 2017

12

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describes a project that uses

4 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4269699/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

SIRT1 and other sirtuins in metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Curcumin ameliorates arterial dysfunction and oxidative stress with aging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

SRT1720 improves survival and healthspan of obese mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Heart disease and stroke statistics--2012 update: a report from the American Heart Association

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Challenges of translating basic research into therapeutics: resveratrol as an example

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

FoxO1 mediates an autofeedback loop regulating SIRT1 expression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Prostacyclin in vascular diseases. - Recent insights and future perspectives -.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Sirt1 activation protects the mouse renal medulla from oxidative injury

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

The molecular inflammatory process in aging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

COX-2 contributes to the maintenance of flow-induced dilation in arterioles of eNOS-knockout mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

NF-kappaB RelA phosphorylation regulates RelA acetylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Metabolism and pharmacokinetics of prostaglandin E1 administered by intravenous infusion in human subjects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Alteration in prostacyclin and prostaglandin E2 production. Correlation with changes in human aortic atherosclerotic disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269699

Sirt1 regulates aging and resistance to oxidative stress in the heart

7 July 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

Selected Contribution: Aging impairs nitric oxide and prostacyclin mediation of endothelium-dependent dilation in soleus feed arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00377.2014

SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans

21 January 2018

1 reference

12 December 2020

Aging‐induced proinflammatory shift in cytokine expression profile in rat coronary arteries

1 reference

12 December 2020

Aging associated with mild dyslipidemia reveals that COX-2 preserves dilation despite endothelial dysfunction

1 reference

12 December 2020

Essential role of endothelial nitric oxide synthase in vascular effects of erythropoietin

1 reference

12 December 2020

Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide

1 reference

12 December 2020

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats

1 reference

12 December 2020

10.1152/AJPHEART.00377.2014

Identifiers

DOI

1 reference

release_av34menkjjgxbmwwljf2z2eesm

4 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/av34menkjjgxbmwwljf2z2eesm

24 November 2022

mapped directly with Wikidata item

PMCID

4269699

1 reference

4 August 2017

1 reference