FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein (Q34695496)

4 August 2017

title

FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein (English)

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4 August 2017

Richard Smith

1

1 reference

4 August 2017

Amy Duguay

2

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4 August 2017

Alice Bakker

3

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4 August 2017

Peng Li

4

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4 August 2017

Jennifer Weiszmann

5

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4 August 2017

Melissa R Thomas

6

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4 August 2017

Benjamin M Alba

7

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4 August 2017

Xinle Wu

8

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4 August 2017

Jamila Gupte

9

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4 August 2017

Li Yang

10

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4 August 2017

Jennitte Stevens

11

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4 August 2017

Agnes Hamburger

12

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4 August 2017

Stephen Smith

13

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4 August 2017

Jiyun Chen

14

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4 August 2017

Renee Komorowski

15

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4 August 2017

Kevin W Moore

16

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4 August 2017

Murielle M Véniant

17

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4 August 2017

Yang Li

18

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4 August 2017

language of work or name

English

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publication date

22 April 2013

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4 August 2017

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4 August 2017

volume

8

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4 August 2017

issue

4

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4 August 2017

page(s)

e61432

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Creative Commons Attribution 4.0 International

4 August 2017

copyright license

start time

22 April 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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7 July 2018

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Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism

7 July 2018

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Understanding the physical interactions in the FGF21/FGFR/β-Klotho complex: structural requirements and implications in FGF21 signaling

7 July 2018

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FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents

7 July 2018

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7 July 2018

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A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation

7 July 2018

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Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis

7 July 2018

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Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects

7 July 2018

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Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice

7 July 2018

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The role of fibroblast growth factor 21 (FGF21) on energy balance, glucose and lipid metabolism

7 July 2018

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7 July 2018

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Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity

7 July 2018

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FGF21: a novel prospect for the treatment of metabolic diseases.

7 July 2018

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Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus.

7 July 2018

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Development, characterization, and evaluation of a fusion protein of a novel glucagon-like peptide-1 (GLP-1) analog and human serum albumin in Pichia pastoris

7 July 2018

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Different roles of N- and C- termini in the functional activity of FGF21

7 July 2018

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FGF21 N- and C-termini play different roles in receptor interaction and activation

7 July 2018

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Fibroblast growth factor 21 corrects obesity in mice

7 July 2018

1 reference

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Fibroblast growth factor-21 as a therapeutic agent for metabolic diseases

7 July 2018

1 reference

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Recombinant therapeutic proteins: production platforms and challenges.

7 July 2018

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Actions and mode of actions of FGF19 subfamily members

7 July 2018

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

7 July 2018

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

7 July 2018

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BetaKlotho is required for metabolic activity of fibroblast growth factor 21

7 July 2018

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The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

7 July 2018

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Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains

7 July 2018

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FGF-21 as a novel metabolic regulator

7 July 2018

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An IFN-beta-albumin fusion protein that displays improved pharmacokinetic and pharmacodynamic properties in nonhuman primates

7 July 2018

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Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

7 July 2018

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FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

7 July 2018

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Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

7 July 2018

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Relation between fibroblast growth factor-21, adiposity, metabolism, and weight reduction

21 January 2018

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Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys

21 January 2018

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Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.

21 January 2018

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Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex

21 January 2018

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Animal models as indicators of immunogenicity of therapeutic proteins in humans

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23630589

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Short communication: renal tubular vacuolation in animals treated with polyethylene-glycol-conjugated proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23630589

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23630589

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0061432

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference