Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation (Q34624754)

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English	Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation	scientific article

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

7 references

25 June 2019

17 September 2019

4 November 2019

7 November 2019

19 November 2019

20 September 2020

14 July 2021

Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation (English)

1 reference

Europe PubMed Central

3 August 2017

radiation therapy

1 reference

20 September 2020

heterocyclic compound

1 reference

17 September 2019

inorganic compound

1 reference

4 November 2019

1 reference

7 November 2019

1 reference

19 November 2019

1 reference

14 July 2021

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Lothar Bohm

1

1 reference

Europe PubMed Central

3 August 2017

publication date

3 May 2006

8 references

Europe PubMed Central

3 August 2017

25 June 2019

17 September 2019

4 November 2019

7 November 2019

19 November 2019

20 September 2020

14 July 2021

Radiation Oncology

8 references

Europe PubMed Central

3 August 2017

25 June 2019

17 September 2019

4 November 2019

7 November 2019

19 November 2019

20 September 2020

14 July 2021

1

1 reference

Europe PubMed Central

3 August 2017

12

1 reference

Europe PubMed Central

3 August 2017

copyright license

Creative Commons Attribution 2.0 Generic

7 references

Europe PubMed Central

25 June 2019

Europe PubMed Central

17 September 2019

Europe PubMed Central

4 November 2019

Europe PubMed Central

7 November 2019

Europe PubMed Central

19 November 2019

Europe PubMed Central

20 September 2020

Europe PubMed Central

14 July 2021

copyright status

0 references

https://scigraph.springernature.com/pub.10.1186/1748-717x-1-12

0 references

Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

A comparison of response to cisplatin, radiation and combined treatment for cells deficient in recombination repair pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Inhibition of DNA repair by Pentoxifylline and related methylxanthine derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Caffeine could not efficiently sensitize homologous recombination repair-deficient cells to ionizing radiation-induced killing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Radiosensitization and DNA repair inhibition by pentoxifylline in NIH3T3 p53 transfectants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

The effects of pentoxifylline on the survival of human glioma cells with continuous and intermittent stereotactic radiosurgery irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Chemosensitivity of prostatic tumour cell lines under conditions of G2 block abrogation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Loss of G2/M arrest correlates with radiosensitization in two human sarcoma cell lines with mutant p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

The many substrates and functions of ATM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Influence of pentoxifylline, A-802710, propentofylline and A-802715 (Hoechst) on the expression of cell cycle blocks and S-phase content after irradiation damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

The DNA damage response: putting checkpoints in perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Abrogation of G(2)/M-phase block enhances the cytotoxicity of daunorubicin, melphalan and cisplatin in TP53 mutant human tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Effect of pentoxifylline on radiation response of non-small cell lung cancer: a phase III randomized multicenter trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

The controlling role of ATM in homologous recombinational repair of DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Potentiation of cytotoxicity and radiosensitization of (E)-2-deoxy-2'-(fluoromethylene) cytidine by pentoxifylline in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Regional perfusion and oxygenation of tumors upon methylxanthine derivative administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Pentoxifylline inhibits hypoxia-induced upregulation of tumor cell tissue factor and vascular endothelial growth factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

A phase II evaluation of pentoxifylline combined with radiation in the treatment of brain metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Effect of pentoxifylline on radiation-induced G2-phase delay and radiosensitivity of human colon and cervical cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Mammalian G1 and G2 phase checkpoints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Increase in tumor blood flow by pentoxifylline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Effect of caffeine on DNA synthesis in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Reduction of radiation-induced cell cycle blocks by caffeine does not necessarily lead to increased cell killing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Participation of p53 protein in the cellular response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Creative blocks: cell-cycle checkpoints and feedback controls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

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Histone Phosphorylation and Chromatin Structure during Mitosis in Chinese Hamster Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

7 July 2018

Tumor radiosensitizers--current status of development of various approaches: report of an International Atomic Energy Agency meeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

Pentoxifylline enhances tumor oxygenation and radiosensitivity in rat rhabdomyosarcomas during continuous hyperfractionated irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

Prophylactic effect of pentoxifylline on radiotherapy complications: a clinical study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

Caffeine-induced radiosensitization is independent of nonhomologous end joining of DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

Influence of irradiation and pentoxifylline on histone H3 phosphorylation in human tumour cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

Radiosensitivity and oxidative signalling in ataxia telangiectasia: an update.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

Cranial radiation and concomitant cisplatin and mitomycin-C plus resistance modulators for malignant gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

Increase in tumor oxygenation and radiosensitivity caused by pentoxifylline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1464387

26 October 2018

The action of caffeine on X-irradiated HeLa cells. IV. Progression delays and enhanced cell killing at high caffeine concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of caffeine on X-irradiated synchronous, asynchronous and plateau phase mouse ascites cells: the importance of progression through the cell cycle for caffeine enhancement of killing

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The action of caffeine on X-irradiated HeLa cells. II. Synergistic lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of pentoxifylline on radiation damage and tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin B1 expression in response to abrogation of the radiation-induced G2/M block in HeLa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological mechanisms of radiation sensitization by pentoxifylline

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comet assay studies indicate that caffeine-mediated increase in radiation risk of embryos is due to inhibition of DNA repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is pentoxifylline the drug of the decade?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between G 2 -Phase Block and Repair of Radiation-Induced Chromosome Fragments in Human Lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of the G2 cell cycle block abrogator pentoxifylline on the expression and subcellular location of cyclin B1 and p34cdc2 in HeLa cervical carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increases in tumor response by pentoxifylline alone or in combination with nicotinamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison between Pulsed-field and Constant-field Gel Electrophoresis for Measurement of DNA Double-strand Breaks in Irradiated Chinese Hamster Ovary Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16722614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1748-717X-1-12

1 reference

Europe PubMed Central

3 August 2017

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0 references

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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