Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease (Q34610487)

3 August 2017

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title

Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease (English)

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3 August 2017

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Hanno M Roder

1

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PubMed ID

17373874

3 August 2017

Michael L Hutton

series ordinal

2

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PubMed ID

17373874

3 August 2017

language of work or name

English

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publication date

1 April 2007

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Expert Opinion on Therapeutic Targets

3 August 2017

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3 August 2017

11

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3 August 2017

4

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3 August 2017

435-442

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Pedigrees of 30 families with Alzheimer disease: Associations with defective organization of microfilaments and microtubules

3 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

A quantitative study of frontal cortex dendritic microtubules in patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Defective brain microtubule assembly in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

An extensive network of PHF tau-rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Tau protein as a differential biomarker of tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.4.435

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Screening for inhibitors of tau polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Aberrant neurofilament phosphorylation in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Prospect of therapeutic approaches to tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1Implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Phosphorylation of microtubule-associated protein tau on Ser 262 by an embryonic 100 kDa protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

MARKing tau for tangles and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Demonstration by fluorescence resonance energy transfer of a close association between activated MAP kinase and neurofibrillary tangles: implications for MAP kinase activation in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Formation of phospho-SAPK/JNK granules in the hippocampus is an early event in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Alzheimer-specific epitope of AT100 in transfected cell lines with tau: toward an efficient cell model of tau abnormal phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

CSF biomarkers for Alzheimer's disease: use in early diagnosis and evaluation of drug treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Neuropathologic features of amnestic mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Abeta species removal after abeta42 immunization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.435

10.1517/14728222.11.4.435

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

17373874