Use of epigenetic drugs in disease: an overview (Q34607095)

3 August 2017

1 reference

title

Use of epigenetic drugs in disease: an overview (English)

1 reference

3 August 2017

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Sarah Heerboth

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Karolina Lapinska

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Nicole Snyder

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Meghan Leary

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Sarah Rollinson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

publication date

27 May 2014

1 reference

3 August 2017

Genetics & Epigenetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

9-19

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

Genetic and epigenetic aspects of breast cancer progression and therapy

11 June 2020

cites work

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7 July 2018

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7 July 2018

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7 July 2018

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

7 July 2018

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Histone deacetylase inhibitors reverse CpG methylation by regulating DNMT1 through ERK signaling

7 July 2018

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The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner

7 July 2018

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

7 July 2018

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Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat.

7 July 2018

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Epigenetic gene promoter methylation at birth is associated with child's later adiposity

7 July 2018

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Atherosclerosis: an epigenetic balancing act that goes wrong

7 July 2018

1 reference

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Hallmarks of Cancer: The Next Generation

7 July 2018

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The path to epigenetic treatment of memory disorders.

7 July 2018

1 reference

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Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases

7 July 2018

1 reference

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T-oligos inhibit growth and induce apoptosis in human ovarian cancer cells

7 July 2018

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Distinct DNA methylation changes highly correlated with chronological age in the human brain

7 July 2018

1 reference

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Ischemic heart disease and stroke in relation to blood DNA methylation

7 July 2018

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Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines

7 July 2018

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Epigenetics and cardiovascular disease

7 July 2018

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Nonhistone protein acetylation as cancer therapy targets

7 July 2018

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Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a

7 July 2018

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Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

7 July 2018

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Epigenetic control of neural precursor cell fate during development

7 July 2018

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Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

7 July 2018

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Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression

7 July 2018

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Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease

7 July 2018

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Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones

7 July 2018

1 reference

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Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

7 July 2018

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Protein methyltransferases as a target class for drug discovery

7 July 2018

1 reference

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Histone acetyl transferases as emerging drug targets.

7 July 2018

1 reference

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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

7 July 2018

1 reference

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Epigenetic mechanisms that underpin metabolic and cardiovascular diseases

7 July 2018

1 reference

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HDAC2 negatively regulates memory formation and synaptic plasticity.

7 July 2018

1 reference

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The critical role of the class III histone deacetylase SIRT1 in cancer

7 July 2018

1 reference

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Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail

7 July 2018

1 reference

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Epigenetics and the control of epithelial sodium channel expression in collecting duct

7 July 2018

1 reference

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Role of HDAC2 in the pathophysiology of COPD.

7 July 2018

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Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

7 July 2018

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Genome-scale DNA methylation maps of pluripotent and differentiated cells

7 July 2018

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Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

7 July 2018

1 reference

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The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats

7 July 2018

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Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy

7 July 2018

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Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.

7 July 2018

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FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma

7 July 2018

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Histone deacetylase inhibitors: overview and perspectives

7 July 2018

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Epigenetics and complex disease: from etiology to new therapeutics

7 July 2018

1 reference

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DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons

7 July 2018

1 reference

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Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice

7 July 2018

1 reference

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A common allele on chromosome 9 associated with coronary heart disease

7 July 2018

1 reference

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Recovery of learning and memory is associated with chromatin remodelling

7 July 2018

1 reference

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Sirtuin functions in health and disease

7 July 2018

1 reference

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The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice

7 July 2018

1 reference

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Reversal of neurological defects in a mouse model of Rett syndrome

7 July 2018

1 reference

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H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability

7 July 2018

1 reference

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Epigenetic gene regulation: linking early developmental environment to adult disease

7 July 2018

1 reference

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Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

7 July 2018

1 reference

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Early nutrition and long-term cardiovascular health

7 July 2018

1 reference

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A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats

7 July 2018

1 reference

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Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study

7 July 2018

1 reference

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DNA methylation and gene silencing in cancer

7 July 2018

1 reference

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Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

7 July 2018

1 reference

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Histone structure and nucleosome stability

7 July 2018

1 reference

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HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.

7 July 2018

1 reference

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

7 July 2018

1 reference

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Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes

7 July 2018

1 reference

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Pharmacology of 5-Aza-2'-deoxycytidine (decitabine).

7 July 2018

1 reference

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Epigenetic differences arise during the lifetime of monozygotic twins

7 July 2018

1 reference

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The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.

7 July 2018

1 reference

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Class II histone deacetylases: from sequence to function, regulation, and clinical implication

7 July 2018

1 reference

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FDA drug approval summary: azacitidine (5-azacytidine, Vidaza) for injectable suspension

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

7 July 2018

1 reference

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Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Selective HAT inhibitors as mechanistic tools for protein acetylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Histone deacetylases (HDACs): characterization of the classical HDAC family

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Chromatin modification and epigenetic reprogramming in mammalian development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Folic acid and homocysteine in age-related disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Bromodomain: an acetyl-lysine binding domain

7 July 2018

1 reference

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DNA methylation patterns and epigenetic memory

7 July 2018

1 reference

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Histone acetylation in chromatin structure and transcription

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

The multistep nature of cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

CpG-rich islands and the function of DNA methylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Oncogenes and anti-oncogenes in tumorigenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

ANRIL expression is associated with atherosclerosis risk at chromosome 9p21.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Detection of altered global DNA methylation in coronary artery disease patients

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Mutant huntingtin represses CBP, but not p300, by binding and protein degradation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Midline carcinoma of children and young adults with NUT rearrangement.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Small molecule modulators of histone acetyltransferase p300.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Inhibition of DNA methylation and reactivation of silenced genes by zebularine

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Anti-angiogenic effects of homocysteine on cultured endothelial cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251063

Aminosuberoyl hydroxamic acids (ASHAs): a potent new class of HDAC inhibitors

26 October 2018

1 reference

12 December 2020

High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats

1 reference

12 December 2020

Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks

1 reference

12 December 2020

Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases

1 reference

12 December 2020

Epigenetic mechanisms in cancer

1 reference

12 December 2020

Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system

1 reference

12 December 2020

Epigenetics and cardiovascular disease

1 reference

12 December 2020

Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms

1 reference

12 December 2020

Do epigenetic drug treatments hold the key to killing cancer progenitor cells?

1 reference

12 December 2020

Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines

1 reference

12 December 2020

Identifiers

DOI

10.4137/GEG.S12270

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25512710%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference