Design of libraries targeting protein-protein interfaces (Q34597781)

3 August 2017

Design of libraries targeting protein-protein interfaces (English)

1 reference

3 August 2017

0 references

5

Klaus Müller

1 reference

3 August 2017

David Fry

1

1 reference

3 August 2017

Kuo-Sen Huang

2

1 reference

3 August 2017

Paola Di Lello

3

1 reference

3 August 2017

Peter Mohr

4

1 reference

3 August 2017

Sung-Sau So

6

1 reference

3 August 2017

Takeo Harada

7

1 reference

3 August 2017

Martin Stahl

8

1 reference

3 August 2017

Binh Vu

9

1 reference

3 August 2017

Harald Mauser

10

1 reference

3 August 2017

21 February 2013

1 reference

3 August 2017

1 reference

3 August 2017

8

1 reference

3 August 2017

726-732

1 reference

3 August 2017

5

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

3 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

MDM2 inhibitors for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Inhibition of a viral enzyme by a small-molecule dimer disruptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Protein farnesyltransferase inhibitors exhibit potent antimalarial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

The Cambridge Structural Database: a quarter of a million crystal structures and rising

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Assessing helical protein interfaces for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Helix-mediated protein--protein interactions as targets for intervention using foldamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Pharmacophore modeling and applications in drug discovery: challenges and recent advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Rationalizing the chemical space of protein-protein interaction inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Virtual screening for compounds that mimic protein-protein interface epitopes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Platelet activation induced by porcine factor VIII (Hyate:C).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Ligand efficiency: a useful metric for lead selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Predicting druggable binding sites at the protein-protein interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Fragment-based lead discovery: leads by design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Determination of the sequence specificity of XIAP BIR domains by screening a combinatorial peptide library

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Efficient synthesis of piperidine derivatives. Development of metal triflate-catalyzed diastereoselective nucleophilic substitution reactions of 2-methoxy- and 2-acyloxypiperidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

Ligand binding efficiency: trends, physical basis, and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

inferred from DOI database lookup

7 January 2021

based on heuristic

NMR structure of a complex between MDM2 and a small molecule inhibitor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200540

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/CMDC.201200540

1 reference

3 August 2017

1 reference