Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio (Q34590536)

3 August 2017

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title

Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio (English)

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3 August 2017

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Brad Bolon

1

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3 August 2017

Elizabeth Galbreath

series ordinal

2

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3 August 2017

publication date

1 January 2002

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International Journal of Toxicology

3 August 2017

published in

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3 August 2017

volume

21

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3 August 2017

issue

1

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3 August 2017

page(s)

55-64

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Cre-mediated somatic site-specific recombination in mice

3 August 2017

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RANK is essential for osteoclast and lymph node development

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Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice

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The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

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Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP

21 January 2018

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Nongenomic transmission across generations of maternal behavior and stress responses in the rat

21 January 2018

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Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes

21 January 2018

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Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

21 January 2018

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The broken mouse: the role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice.

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Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis

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Pathophysiology of gene-targeted mouse models for cystic fibrosis

21 January 2018

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

21 January 2018

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Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2

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Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice

21 January 2018

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21 January 2018

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High resolution MRI and MRS: a feasibility study for the investigation of focal cerebral ischemia in mice

21 January 2018

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Intraamniotic administration of an adenoviral vector for gene transfer to fetal sheep and mouse tissues

21 January 2018

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Developing mouse models of aging: a consideration of strain differences in age-related behavioral and neural parameters

21 January 2018

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Rescue of angiotensinogen-knockout mice.

21 January 2018

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21 January 2018

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Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

21 January 2018

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Altering genes in animals by gene targeting

21 January 2018

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

21 January 2018

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

21 January 2018

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Near-microscopic magnetic resonance imaging of the brains of phenylalanine hydroxylase-deficient mice, normal littermates, and of normal BALB/c mice at 9.4 Tesla.

21 January 2018

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Generation and reproductive phenotypes of mice lacking estrogen receptor beta

21 January 2018

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Qualitative and quantitative decline in spermatogenesis of the follicle-stimulating hormone receptor knockout (FORKO) mouse

21 January 2018

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Inducible gene targeting in mice

21 January 2018

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Reinforcing and neurochemical effects of cocaine: differences among C57, DBA, and 129 mice.

21 January 2018

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In vivo analysis of Pim-1 deficiency

21 January 2018

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The hypertensive Ren-2 transgenic rat TGR (mREN2)27 in hypertension research. Characteristics and functional aspects

21 January 2018

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An adenovirus vector for gene transfer into neurons and glia in the brain

21 January 2018

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Differential Gene Expression of Renin and Angiotensinogen in the TGR(mREN-2)27 Transgenic Rat

21 January 2018

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RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

21 January 2018

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Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

21 January 2018

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Transgenic animals in the evaluation of compound efficacy and toxicity: will they be as useful as they are novel?

21 January 2018

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Maternal care, hippocampal synaptogenesis and cognitive development in rats.

21 January 2018

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Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress

21 January 2018

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In vivo visualization of gene expression using magnetic resonance imaging

21 January 2018

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Regional metabolic disturbances and cerebrovascular anatomy after permanent middle cerebral artery occlusion in C57black/6 and SV129 mice

21 January 2018

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The use of genetically modified animals in carcinogenicity bioassays

21 January 2018

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Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants

21 January 2018

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Legless, a Novel Mutation Found in PHT1-1 Transgenic Mice

21 January 2018

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Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

21 January 2018

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Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis

21 January 2018

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Transgenic animal models for measuring mutations in vivo

21 January 2018

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Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin

21 January 2018

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Quantitative evaluation of left ventricular function in a TransgenicMouse model of dilated cardiomyopathy with 2-dimensional contrast echocardiography.

21 January 2018

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Targeted mutagenesis: analysis of phenotype without germ line transmission

21 January 2018

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How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress

21 January 2018

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GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion

21 January 2018

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Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

21 January 2018

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Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes

21 January 2018

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Increased anxiety of mice lacking the serotonin1A receptor

21 January 2018

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Regulated expression of foreign genes in vivo after germline transfer.

21 January 2018

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Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)

21 January 2018

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Long-range disruption of gene expression by a selectable marker cassette

21 January 2018

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Complications associated with genetic background effects in research using knockout mice

21 January 2018

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Transgenic mice in drug dependence research.

21 January 2018

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Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2

21 January 2018

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Serotonin receptor 1A knockout: an animal model of anxiety-related disorder

21 January 2018

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Tracking Alzheimer's disease in transgenic mice using fluorodeoxyglucose autoradiography.

21 January 2018

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Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression

21 January 2018

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Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene

21 January 2018

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Viral vectors for gene therapy

21 January 2018

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Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

21 January 2018

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Genome manipulation in embryonic stem cells

21 January 2018

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In vivo magnetic resonance methods in pharmaceutical research: current status and perspectives

21 January 2018

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Genetically modified animals in pharmacological research: future trends

21 January 2018

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Impact of knockout mice in toxicology

21 January 2018

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5-HT receptor knockout mice: pharmacological tools or models of psychiatric disorders.

21 January 2018

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Temporally and spatially regulated somatic mutagenesis in mice

21 January 2018

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21 January 2018

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A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor

21 January 2018

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

21 January 2018

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Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase.

21 January 2018

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Initial experiences and future directions for transgenic mouse mutation assays

21 January 2018

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FVB/N: an inbred mouse strain preferable for transgenic analyses

21 January 2018

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The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats

21 January 2018

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Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models

21 January 2018

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Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2

21 January 2018

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An inbred colony of oncogene transgenic mice: diversity of tumours and potential as a therapeutic model

21 January 2018

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An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness.

21 January 2018

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Subregion- and cell type-restricted gene knockout in mouse brain

21 January 2018

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Transgenesis by adenovirus-mediated gene transfer into mouse zona-free eggs.

21 January 2018

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Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis

21 January 2018

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A transgenic mouse expressing human CYP1A2 in the pancreas

21 January 2018

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Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells

21 January 2018

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Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver

21 January 2018

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Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor

21 January 2018

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An inherited limb deformity created by insertional mutagenesis in a transgenic mouse

21 January 2018

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Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

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Quantification of target gene expression by imaging reporter gene expression in living animals.

21 January 2018

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Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation

21 January 2018

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Magnetic resonance microscopy of the C57BL mouse brain

21 January 2018

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Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

21 January 2018

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Maternal age and traits in offspring

21 January 2018

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Non-injection methods for the production of embryonic stem cell-embryo chimaeras

21 January 2018

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10.1080/10915810252826019

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference