Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1 (Q34572977)

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17 January 2020

title

Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1 (English)

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17 January 2020

8

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17 January 2020

author name string

Wei-Ming Chien

1

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17 January 2020

Stuart Rabin

2

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17 January 2020

Everardo Macias

3

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17 January 2020

Paula L Miliani de Marval

4

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17 January 2020

Kendra Garrison

5

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17 January 2020

Jason Orthel

6

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17 January 2020

Marcelo Rodriguez-Puebla

7

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17 January 2020

language of work or name

English

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publication date

3 March 2006

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Proceedings of the National Academy of Sciences of the United States of America

17 January 2020

published in

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17 January 2020

volume

103

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17 January 2020

page(s)

4122-4127

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17 January 2020

issue

11

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Tumor suppressor genetics

17 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Cytokines in the thymus: production and biological effects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Transgenic expression of cyclin-dependent kinase 4 results in epidermal hyperplasia, hypertrophy, and severe dermal fibrosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Androgen receptors in thymic epithelium modulate thymus size and thymocyte development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Cyclin D2 overexpression in transgenic mice induces thymic and epidermal hyperplasia whereas cyclin D3 expression results only in epidermal hyperplasia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Generalized lacZ expression with the ROSA26 Cre reporter strain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Cyclin E-CDK2 is a regulator of p27Kip1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1449657

Stem cell repopulation efficiency but not pool size is governed by p27(kip1).

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0509514103

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0509514103

Cytokine-stimulated T lymphocyte proliferation is regulated by p27Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0509514103

Effects of alpha-MSH on progesterone and nitric oxide release by cultured ovarian granulosa cells in experimental rat autoimmune oophoritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0509514103

p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0509514103

p27Kip1-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0509514103

Regulation of thymic epithelium by keratinocyte growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0509514103

The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition

21 January 2018

1 reference

12 December 2020

Widespread recombinase expression using FLPeR (flipper) mice

1 reference

12 December 2020

p27Kip1 regulates T cell proliferation

1 reference

12 December 2020

The homeostasis but not the differentiation of T cells is regulated by p27(Kip1)

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0509514103

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17 January 2020

0 references

1 reference

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17 January 2020

1 reference