Clk/STY (cdc2-like kinase 1) and Akt regulate alternative splicing and adipogenesis in 3T3-L1 pre-adipocytes (Q34544872)

2 August 2017

title

Clk/STY (cdc2-like kinase 1) and Akt regulate alternative splicing and adipogenesis in 3T3-L1 pre-adipocytes (English)

1 reference

alternative mRNA splicing, via spliceosome

2 August 2017

1 reference

1 reference

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Pengfei Li

1

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2 August 2017

Gay Carter

2

1 reference

2 August 2017

Jacqueline Romero

3

1 reference

2 August 2017

Kathryn M Gower

4

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2 August 2017

James Watson

5

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2 August 2017

Niketa A Patel

6

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2 August 2017

Denise R Cooper

7

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2 August 2017

language of work or name

English

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publication date

4 January 2013

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2 August 2017

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2 August 2017

volume

8

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2 August 2017

issue

1

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2 August 2017

page(s)

e53268

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Creative Commons CC0 License

2 August 2017

copyright license

start time

4 January 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

cites work

Phosphorylation of CLK2 at Serine 34 and Threonine 127 by AKT Controls Cell Survival after Ionizing Radiation

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Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors.

7 July 2018

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Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

7 July 2018

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Developmentally spliced PKCbetaII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance

7 July 2018

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Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation

7 July 2018

1 reference

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Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid

7 July 2018

1 reference

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Alternative isoform regulation in human tissue transcriptomes

7 July 2018

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Mechanisms for the anti-inflammatory effects of adiponectin in macrophages

7 July 2018

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PKBalpha is required for adipose differentiation of mouse embryonic fibroblasts

7 July 2018

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From mice to men: insights into the insulin resistance syndromes

7 July 2018

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Protein kinase clk/STY is differentially regulated during erythroleukemia cell differentiation: a bias toward the skipped splice variant characterizes postcommitment stages

7 July 2018

1 reference

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Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40

7 July 2018

1 reference

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Manipulation of alternative splicing by a newly developed inhibitor of Clks

7 July 2018

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Insulin regulates protein kinase CbetaII alternative splicing in multiple target tissues: development of a hormonally responsive heterologous minigene.

7 July 2018

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Regulation and substrate specificity of the SR protein kinase Clk/Sty

7 July 2018

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7 July 2018

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Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells

7 July 2018

1 reference

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Molecular regulation of adipogenesis

7 July 2018

1 reference

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Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1

7 July 2018

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Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

7 July 2018

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SR protein kinases: the splice of life

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

SR proteins are sufficient for exon bridging across an intron

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

Insulin regulates protein kinase CbetaII expression through enhanced exon inclusion in L6 skeletal muscle cells. A novel mechanism of insulin- and insulin-like growth factor-i-induced 5' splice site selection

7 July 2018

1 reference

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In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

Activity and autophosphorylation of LAMMER protein kinases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

The Doa locus encodes a member of a new protein kinase family and is essential for eye and embryonic development in Drosophila melanogaster

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

Regulation of alternative splicing of protein kinase C beta by insulin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

Alternative splicing of STY, a nuclear dual specificity kinase.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

Formation of normally differentiated subcutaneous fat pads by an established preadipose cell line

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537621

Peroxisome proliferator activated receptor gamma, CCAAT/enhancer-binding protein alpha, and cell cycle status regulate the commitment to adipocyte differentiation

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053268

The relative strengths of SR protein-mediated associations of alternative and constitutive exons can influence alternative splicing

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23308182

12 December 2020

inferred from PubMed ID database lookup

Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Bα

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23308182

12 December 2020

inferred from PubMed ID database lookup

Paraspeckles: a novel nuclear domain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23308182

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PONE.0053268

1 reference

release_4asb6ljttvbrbkugvb6ydt6kvu

2 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4asb6ljttvbrbkugvb6ydt6kvu

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3537621

1 reference

2 August 2017

1 reference