Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects (Q34505760)

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English	Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects (English)

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Europe PubMed Central

PubMed publication ID

2 August 2017

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author name string

Ingo Flamme

1

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Europe PubMed Central

PubMed publication ID

2 August 2017

Felix Oehme

2

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Europe PubMed Central

PubMed publication ID

2 August 2017

Peter Ellinghaus

3

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Europe PubMed Central

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2 August 2017

Mario Jeske

4

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Europe PubMed Central

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2 August 2017

Jörg Keldenich

5

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Europe PubMed Central

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2 August 2017

Uwe Thuss

6

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2 August 2017

language of work or name

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publication date

13 November 2014

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Europe PubMed Central

PubMed publication ID

2 August 2017

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Europe PubMed Central

PubMed publication ID

2 August 2017

9

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Europe PubMed Central

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2 August 2017

11

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Europe PubMed Central

PubMed publication ID

2 August 2017

e111838

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Europe PubMed Central

PubMed publication ID

2 August 2017

copyright license

Creative Commons Attribution 4.0 International

13 November 2014

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April 2022 Public Data File from Crossref

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0 references

A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism

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Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses

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Effects of recombinant human erythropoietin on resistance artery endothelial function in stage 4 chronic kidney disease

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Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells

1 reference

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7 July 2018

Hypertension management: rationale for triple therapy based on mechanisms of action

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Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis

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Dose of erythropoiesis-stimulating agents and adverse outcomes in CKD: a metaregression analysis

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Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

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Oxygen sensing, homeostasis, and disease

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HIF prolyl hydroxylase inhibitors for anemia

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7 July 2018

The effect of altitude change on anemia treatment response in hemodialysis patients

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Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

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7 July 2018

The HIF pathway and erythrocytosis

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7 July 2018

Hepcidin and disorders of iron metabolism

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7 July 2018

Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade

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7 July 2018

Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

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7 July 2018

Reactivation of hepatic EPO synthesis in mice after PHD loss

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7 July 2018

Regulation of human metabolism by hypoxia-inducible factor

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7 July 2018

Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells

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Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha

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7 July 2018

Hyporesponsiveness to erythropoietin: causes and management

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7 July 2018

Arterial hypertension induced by erythropoietin and erythropoiesis-stimulating agents (ESA).

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7 July 2018

The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors

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7 July 2018

The effect of altitude on dosing and response to erythropoietin in ESRD

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7 July 2018

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

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7 July 2018

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

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7 July 2018

von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis

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7 July 2018

Erythropoiesis-stimulating agent hyporesponsiveness.

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7 July 2018

The role of the kidney in blood volume regulation: the kidney as a regulator of the hematocrit

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7 July 2018

Pathogenesis of renal anemia

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7 July 2018

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

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7 July 2018

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

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Integration of oxygen signaling at the consensus HRE.

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7 July 2018

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).

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7 July 2018

Anemia of chronic disease.

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7 July 2018

Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression

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Oxygen sensing by HIF hydroxylases

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Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

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Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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A conserved family of prolyl-4-hydroxylases that modify HIF

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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Induction of HIF-1alpha in response to hypoxia is instantaneous

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Effect of recombinant human erythropoietin on new anaemic model rats induced by gentamicin

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21 January 2018

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27 October 2018

Effects of reduction of renal mass on renal oxygen tension and erythropoietin production in the rat

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Transient hypoxia-inducible factor activation in rat renal ablation and reduced fibrosis with L-mimosine

1 reference

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Sensitive ELISA for mouse erythropoietin

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A modular polycistronic expression system for overexpressing protein complexes in Escherichia coli

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based on heuristic

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Erythropoietin production in patients with chronic renal failure

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https://pubmed.ncbi.nlm.nih.gov/25392999

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based on heuristic

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Comparison of gentamicin nephrotoxicity between rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

12 December 2020

based on heuristic

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Effects of hypoxia on growth factor expression in the rat kidney in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

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based on heuristic

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Update on clinical practice recommendations and new therapeutic modalities for treating anemia in patients with chronic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

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Erythropoiesis-stimulating agents--time for a reevaluation

1 reference

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Identifiers

10.1371/JOURNAL.PONE.0111838

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2014PLoSO...9k1838F

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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