A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes (Q34489496)

2 August 2017

A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes (English)

1 reference

2 August 2017

8

Peter G Schultz

1 reference

2 August 2017

Jennifer L Furman

1

1 reference

2 August 2017

Mingchao Kang

2

1 reference

2 August 2017

Seihyun Choi

3

1 reference

2 August 2017

Yu Cao

4

1 reference

2 August 2017

Erik D Wold

5

1 reference

2 August 2017

Sophie B Sun

6

1 reference

2 August 2017

Vaughn V Smider

7

1 reference

2 August 2017

Chan Hyuk Kim

9

1 reference

2 August 2017

language of work or name

English

0 references

publication date

30 May 2014

1 reference

Journal of the American Chemical Society

2 August 2017

1 reference

2 August 2017

136

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2 August 2017

23

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2 August 2017

8411-8417

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describes a project that uses

2 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4227728/fullTextXML

inferred from PubMed Central ID database lookup

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Image-guided cancer surgery using near-infrared fluorescence

6 July 2018

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Expanding the genetic code for photoclick chemistry in E. coli, mammalian cells, and A. thaliana

6 July 2018

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A genetically encoded acrylamide functionality

6 July 2018

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Developing irreversible inhibitors of the protein kinase cysteinome

6 July 2018

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Protein organic chemistry and applications for labeling and engineering in live-cell systems

6 July 2018

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Diverse functional roles of reactive cysteines

6 July 2018

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Site-specific incorporation of ε-N-crotonyllysine into histones

6 July 2018

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Drug discovery for a new generation of covalent drugs

6 July 2018

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Enhancing peptide ligand binding to vascular endothelial growth factor by covalent bond formation.

6 July 2018

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The pharmacological landscape and therapeutic potential of serine hydrolases

6 July 2018

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Chemical genetic strategy for targeting protein kinases based on covalent complementarity

6 July 2018

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The resurgence of covalent drugs

6 July 2018

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An Evolved Aminoacyl-tRNA Synthetase with Atypical Polysubstrate Specificity,

6 July 2018

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Expanding the genetic code of yeast for incorporation of diverse unnatural amino acids via a pyrrolysyl-tRNA synthetase/tRNA pair

6 July 2018

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Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

6 July 2018

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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

6 July 2018

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A genetically encoded epsilon-N-methyl lysine in mammalian cells

6 July 2018

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Protein chemical modification on endogenous amino acids.

6 July 2018

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Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.

6 July 2018

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A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies

6 July 2018

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Electrophilic affibodies forming covalent bonds to protein targets

6 July 2018

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Bioorthogonal chemistry: fishing for selectivity in a sea of functionality

6 July 2018

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Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

6 July 2018

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Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery

6 July 2018

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Covalent modifiers: an orthogonal approach to drug design

6 July 2018

1 reference

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Michael acceptors as cysteine protease inhibitors.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227728

Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology

6 July 2018

1 reference

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Analysis of accessible surface of residues in proteins

6 July 2018

1 reference

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

6 July 2018

1 reference

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Addition of the keto functional group to the genetic code of Escherichia coli.

6 July 2018

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Irreversible inhibitors of serine, cysteine, and threonine proteases

6 July 2018

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Antibodies with infinite affinity

6 July 2018

1 reference

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Expanding the genetic code of Escherichia coli

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227728

Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

6 July 2018

1 reference

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Humanization of an anti-p185HER2 antibody for human cancer therapy

6 July 2018

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Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones.

6 July 2018

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Genetically encoding N(epsilon)-acetyllysine in recombinant proteins.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227728

Relative rates of Michael reactions of 2'-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors

27 October 2018

1 reference

12 December 2020

Monoclonal antibody therapy of cancer

1 reference

12 December 2020

Genetic incorporation of an aliphatic keto-containing amino acid into proteins for their site-specific modifications

1 reference

12 December 2020

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

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12 December 2020

Identifiers

DOI

10.1021/JA502851H

1 reference

2 August 2017

1 reference

2 August 2017

1 reference