Chemical genetic strategy for targeting protein kinases based on covalent complementarity (Q27671824)

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11 February 2020

title

Chemical genetic strategy for targeting protein kinases based on covalent complementarity (English)

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11 February 2020

2

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11 February 2020

author name string

Adam L Garske

1

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11 February 2020

Arianna T Cortesi

3

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Jenny L Perez

4

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11 February 2020

Kevan M Shokat

5

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11 February 2020

language of work or name

English

0 references

publication date

18 August 2011

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Proceedings of the National Academy of Sciences of the United States of America

11 February 2020

published in

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11 February 2020

volume

108

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11 February 2020

issue

37

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11 February 2020

page(s)

15046-15052

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

11 February 2020

cites work

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A new screening assay for allosteric inhibitors of cSrc

20 March 2017

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Small Molecule Recognition of c-Src via the Imatinib-Binding Conformation

20 March 2017

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Activation of tyrosine kinases by mutation of the gatekeeper threonine

20 March 2017

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Cysteine p K a Depression by a Protonated Glutamic Acid in Human DJ-1

20 March 2017

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Structure-guided development of affinity probes for tyrosine kinases using chemical genetics

20 March 2017

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Molecular cloning and characterization of a novel member of the MAP kinase superfamily

20 March 2017

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Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

20 March 2017

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Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2.

20 March 2017

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Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p

20 March 2017

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Irreversible inhibitors of serine, cysteine, and threonine proteases

20 March 2017

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Protease inhibitors: current status and future prospects

20 March 2017

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The interpretation of protein structures: Total volume, group volume distributions and packing density

20 March 2017

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The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B

20 March 2017

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Targeting cancer with small molecule kinase inhibitors

20 March 2017

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

7 April 2017

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Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

7 April 2017

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A chemical switch for inhibitor-sensitive alleles of any protein kinase

7 April 2017

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Crizotinib, a small-molecule dual inhibitor of the c-Met and ALK receptor tyrosine kinases.

7 April 2017

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Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

29 September 2017

1 reference

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Activity-based protein profiling for biochemical pathway discovery in cancer

29 September 2017

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Sorafenib: a clinical and pharmacologic review

29 September 2017

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Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

29 September 2017

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Through the "gatekeeper door": exploiting the active kinase conformation

29 September 2017

1 reference

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Inhibitor hijacking of Akt activation

29 September 2017

1 reference

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Application of activity-based probes to the study of enzymes involved in cancer progression

29 September 2017

1 reference

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Recognizing and exploiting differences between RNAi and small-molecule inhibitors

29 September 2017

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Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase

29 September 2017

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Applying the discovery of the Philadelphia chromosome

29 September 2017

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A clickable inhibitor reveals context-dependent autoactivation of p90 RSK

29 September 2017

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Chemical rescue of a mutant enzyme in living cells

29 September 2017

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Structural bioinformatics-based design of selective, irreversible kinase inhibitors

29 September 2017

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Chemical genetic approaches for the elucidation of signaling pathways

29 September 2017

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A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

29 September 2017

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Crystal structures of active SRC kinase domain complexes

2 June 2018

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Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling

2 June 2018

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Design of allele-specific inhibitors to probe protein kinase signaling

2 June 2018

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Electrostatic interactions in the active site of the N-terminal thioredoxin-like domain of protein disulfide isomerase

2 June 2018

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Ionisation of cysteine residues at the termini of model alpha-helical peptides. Relevance to unusual thiol pKa values in proteins of the thioredoxin family.

2 June 2018

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The (un)targeted cancer kinome

2 June 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1111239108

A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1111239108

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

21 January 2018

1 reference

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Exo-mechanism proximity-accelerated alkylations: investigations of linkers, electrophiles and surface mutations in engineered cyclophilin-cyclosporin systems

21 January 2018

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A kinase sequence database: sequence alignments and family assignment

21 January 2018

1 reference

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Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1111239108

Relative rates of Michael reactions of 2'-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21852571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Selective inhibition of engineered receptors via proximity-accelerated alkylation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21852571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1111239108

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21852571%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

ADS bibcode

2011PNAS..10815046G

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21852571%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

2 references