Mechanism of action of general anaesthetics--new information from molecular pharmacology (Q34442065)

2 August 2017

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title

Mechanism of action of general anaesthetics--new information from molecular pharmacology (English)

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2 August 2017

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Thompson SA

1

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PubMed ID

11712540

2 August 2017

Wafford K

series ordinal

2

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2 August 2017

1 February 2001

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Current Opinion in Pharmacology

2 August 2017

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2 August 2017

1

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2 August 2017

1

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2 August 2017

78-83

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Contributions to the theory of narcosis

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type A receptors and animals

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

General anaesthetic actions on ligand-gated ion channels

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Stereoselective loss of righting reflex in rats by isoflurane.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Stereoselective and non-stereoselective actions of isoflurane on the GABAA receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published]

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Molecular determinants of general anesthetic action: role of GABAA receptor structure.

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic.

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

A designed four-alpha-helix bundle that binds the volatile general anesthetic halothane with high affinity

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon.

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Volatile general anaesthetics activate a novel neuronal K+ current

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Molecular and functional properties of two-pore-domain potassium channels.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

The structure, function and distribution of the mouse TWIK-1 K+ channel

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

TASK-3, a new member of the tandem pore K(+) channel family

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

TASK, a human background K+ channel to sense external pH variations near physiological pH

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Inhalational anesthetics activate two-pore-domain background K+ channels

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Modulation of cardiac inward rectifier K(+)current by halothane and isoflurane

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

The influence of the gamma 2L subunit on the modulation of responses to GABAA receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Functional characteristics of recombinant human GABA(A) receptors containing the epsilon-subunit

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Bicuculline, pentobarbital and diazepam modulate spontaneous GABA(A) channels in rat hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

A Structural Determinant of Desensitization and Allosteric Regulation by Pentobarbitone of the GABA A Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

A single amino acid confers barbiturate sensitivity upon the GABA rho 1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Intravenous anesthetics differentially modulate ligand-gated ion channels.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Subunit-dependent inhibition of human neuronal nicotinic acetylcholine receptors and other ligand-gated ion channels by dissociative anesthetics ketamine and dizocilpine.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

A transmembrane site determines sensitivity of neuronal nicotinic acetylcholine receptors to general anesthetics.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Effects of thiopental and its optical isomers on nicotinic acetylcholine receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Propofol potentiates ATP-activated currents of recombinant P2X(4) receptor channels expressed in human embryonic kidney 293 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Molecular and cellular mechanisms of general anaesthesia

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Allosteric modulation of 5-HT3 receptors: focus on alcohols and anaesthetic agents

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https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4892%2801%2900013-3

7 January 2021

10.1016/S1471-4892(01)00013-3

Identifiers

DOI

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2 August 2017

1 reference

PubMed ID

11712540