PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis. (Q34428066)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23028778%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis (English)

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1

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author name string

Wendel Litchfield

series ordinal

2

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9 March 2020

Ervin Kara

series ordinal

3

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Shaun R McColl

series ordinal

4

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language of work or name

English

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publication date

13 September 2012

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9 March 2020

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volume

7

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issue

9

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9 March 2020

page(s)

e45095

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Creative Commons Attribution 4.0 International

9 March 2020

copyright license

start time

13 September 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells

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6 July 2018

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6 July 2018

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Leukocyte phosphoinositide-3 kinase {gamma} is required for chemokine-induced, sustained adhesion under flow in vivo

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation.

6 July 2018

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PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome.

27 October 2018

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Absence of PI3Kgamma leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis.

27 October 2018

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PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis

27 October 2018

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Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response.

27 October 2018

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Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice.

27 October 2018

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Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation.

27 October 2018

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Antagonism of the chemokine receptors CXCR3 and CXCR4 reduces the pathology of experimental autoimmune encephalomyelitis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441529

PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441529

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441529

Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441529

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441529

PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

27 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441529

Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.

27 October 2018

1 reference

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Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing

27 October 2018

1 reference

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Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441529

Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441529

Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441529

Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1.

27 October 2018

1 reference

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A role for macrophage inflammatory protein-3 alpha/CC chemokine ligand 20 in immune priming during T cell-mediated inflammation of the central nervous system

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441529

Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs.

27 October 2018

1 reference

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The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

27 October 2018

1 reference

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IFN differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract

27 October 2018

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Cutting edge: stromal cell-derived factor-1 is a costimulator for CD4+ T cell activation

9 December 2018

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12 December 2020

T cell costimulation by chemokine receptors

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12 December 2020

CXCR4 physically associates with the T cell receptor to signal in T cells

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12 December 2020

Immunology of multiple sclerosis

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12 December 2020

The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses

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12 December 2020

10.1371/JOURNAL.PONE.0045095

Identifiers

DOI

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9 March 2020

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9 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23028778%20AND%20SRC:MED&resulttype=core&format=json